光照和昼夜节律线索塑造斑马鱼幼鱼用于平衡和导航的运动策略。

文献信息

中文摘要

大多数鱼类本质上是不稳定的，必须通过游动来稳定姿势。昼行性鱼类如何在夜间减少活动同时维持姿势控制仍不清楚。我们定义了斑马鱼幼鱼（Danio rerio）响应光照和昼夜节律线索时用于控制姿势和在水柱中导航的不同运动策略。在黑暗中，幼鱼通过长时间、大幅度的鼻部上仰旋转游动来维持平衡，以补偿长时间不活动期间累积的鼻部下倾漂移。有效的姿势补偿需要来自椭圆囊的前庭感觉。相比之下，在光照下，幼鱼以短暂、频繁且多变的游动片段进行导航。虽然光照对运动策略产生主导性的掩蔽效应，但昼夜节律调节游动运动学。我们的结果揭示了不同的光-暗运动策略，并阐明了环境光和内部时钟如何共同塑造平衡控制和导航。这项工作为理解外部和内部线索如何相互作用以调控自由活动的昼行性动物的运动活动奠定了基础。

英文摘要

Most fish are inherently unstable and must swim to stabilize posture. How diurnal fish reduce activity at night while maintaining postural control remains unclear. We defined distinct locomotor strategies that larval zebrafish (Danio rerio) use to control posture and navigate the water column in response to light and circadian cues. In the dark, larvae maintain balance by swimming in long bouts with large nose-up rotations, compensating for nose-down drift accrued during prolonged inactivity. Effective postural compensation requires vestibular sensation from the utricle. By contrast, in the light, larvae navigate with short, frequent and variable bouts. While lighting exerts a dominant, masking effect on the locomotor strategies, circadian rhythms modulate swim kinematics. Our results reveal distinct light-dark locomotor strategies and disentangle how ambient light and the internal clock jointly shape balance control and navigation. This work lays the foundation for understanding how external and internal cues interact to govern locomotor activity in freely moving diurnal animals.