中国火灾来源PM2.5的极端、累积和滞后暴露与特定部位癌症风险
Extreme, Accumulated, and Lagged Exposure to Fire-Sourced PM2.5 and Site-specific Cancer Risk in China.
文献信息
| PMID | 42869373 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Honglin Zhu |
| 作者单位 | Department of Urban Planning and Design, Urban Systems Institute, the Social Infrastructure for Equity and Wellbeing (SIEW) Lab, the Hong Kong Base of the State Key Laboratory of Subtropical Building and Urban Science, The University of Hong Kong, Hong Kong SAR, China. |
| 期刊 | Environmental pollution (Barking, Essex : 1987) |
| SCI 分区 | Q1 |
| IF | 8 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
火灾来源细颗粒物（PM2.5）是环境空气污染中一种化学性质独特的组分，但其与特定部位癌症风险的关联仍知之甚少。在此，我们使用滞后、累积和极端暴露指标，研究中国范围内火灾来源PM2.5与多种特定部位癌症之间的关联，并将其与全来源PM2.5的关联进行比较。火灾来源PM2.5与多种癌症呈正相关，尽管其模式因暴露指标和癌症部位而异。滞后和累积暴露显示出最广泛的关联，尤其是甲状腺癌、肾癌、乳腺癌、肺癌、白血病和淋巴瘤；而极端暴露显示出较窄的模式，与喉癌的关联最强。与全来源PM2.5相比，火灾来源PM2.5与甲状腺癌、肾癌、喉癌、淋巴瘤和口腔癌显示出更强且更一致的关联，提示总PM2.5质量可能掩盖来源特异性的癌症风险。女性中甲状腺癌和肺癌的关联更强，男性中肾癌的关联更强，并且在北方地区以及国内生产总值（GDP）较低或第三产业占比较低的地区，关联通常更为明显。这些发现将火灾来源PM2.5确定为一种独特的癌症相关暴露，并支持来源特异性和以健康促进为导向的空气污染控制策略，尤其是在社会经济弱势地区。
英文摘要
Fire-sourced fine particulate matter (PM2.5) is a chemically distinct component of ambient air pollution, but its association with site-specific cancer risk remains poorly understood. Here we examine associations between fire-sourced PM2.5 and multiple site-specific cancers across China using lagged, accumulated and extreme exposure metrics, and compare them with those for all-source PM2.5. Fire-sourced PM2.5 is positively associated with several cancers, although the pattern varies by exposure metric and cancer site. Lagged and accumulated exposures show the broadest associations, particularly for thyroid, kidney, breast, lung, leukemia and lymphoma cancers, whereas extreme exposure shows a narrower pattern, with the strongest association for laryngeal cancer. Compared with all-source PM2.5, fire-sourced PM2.5 shows stronger and more consistent associations with thyroid, kidney, laryngeal, lymphoma and oral cancers, suggesting that total PM2.5 mass may obscure source-specific cancer risks. Associations are stronger for thyroid and lung cancers in females and for kidney cancer in males, and are generally more pronounced in northern regions and in areas with lower gross domestic product (GDP) or lower tertiary-industry share. These findings identify fire-sourced PM2.5 as a distinct cancer-related exposure and support source-specific and health promotion-oriented air-pollution control strategies, particularly in socioeconomically disadvantaged regions.