斋月禁食与慢性鼻窦炎症状改善的相关性

文献信息

中文摘要

背景： 慢性鼻窦炎（CRS）是一种常见疾病，会显著损害生活质量。尽管斋月禁食（RF）已显示出对鼻腔生理的影响，但其对CRS患者鼻窦症状的影响仍不清楚。目的：本研究旨在探讨CRS患者在斋月禁食期间的症状变化。方法：这项前瞻性研究纳入了42名男性CRS患者和42名健康男性个体。参与者接受了鼻内镜评估，并记录其Lund-Kennedy评分。使用视觉模拟量表（VAS）在第0天、斋月禁食的第一天和最后一天（第1天和第30天）以及研究结束时（第210天）评估鼻窦症状，包括鼻塞、鼻漏、后鼻滴漏、嗅觉障碍、面部疼痛/压迫感、头痛和总体症状。在第0天和第210天记录参与者的体重，并对收集的数据进行统计分析。结果：患者在所有研究日的评分均显著高于健康个体。在不同研究时期，鼻塞、鼻漏、后鼻滴漏、嗅觉障碍和总体症状均观察到显著差异。在第0天，鼻塞、鼻漏和后鼻滴漏的评分显著高于第1天和第30天。与第30天相比，第0天的嗅觉障碍和总体症状也更高。在第210天，鼻漏和后鼻滴漏评分显著高于第1天和第30天，而鼻塞、嗅觉障碍和总体症状高于第30天（p < 0.05）。结论：本研究表明，斋月禁食与CRS患者鼻塞、鼻漏、后鼻滴漏、嗅觉障碍和总体鼻窦症状的暂时改善相关。

英文摘要

BackgroundChronic rhinosinusitis (CRS) is a common disease that markedly impairs quality of life. Although Ramadan fasting (RF) has demonstrated influences on nasal physiology, its effects on sinonasal symptoms in CRS patients remain unclear.ObjectiveThis study aimed to investigate the symptom changes of patients with CRS during RF.MethodsThis prospective study included 42 male CRS patients and 42 healthy male individuals. Participants underwent nasal endoscopic evaluations, and their Lund-Kennedy scores were recorded. Sinonasal symptoms, including nasal congestion, nasal discharge, postnasal drip, olfactory disturbance, facial pain/pressure, headache, and overall symptoms, were assessed using a visual analog scale (VAS) on day 0, the first and last days of RF (days 1 and 30), and at the study's end (day 210). Participants' body weights were recorded on days 0 and 210, and the collected data were analyzed statistically.ResultsThe patients' scores were significantly higher than those of healthy individuals on all study days. Significant differences were observed in nasal congestion, nasal discharge, postnasal drip, olfactory disturbance, and overall symptoms at various study periods. On day 0, scores for nasal congestion, nasal discharge, and postnasal drip were significantly higher than on days 1 and 30. Olfactory disturbance and overall symptoms were also higher on day 0 compared to day 30. On day 210, nasal discharge and postnasal drip scores were significantly higher than on days 1 and 30, while nasal congestion, olfactory disturbance, and overall symptoms were higher than on day 30 (p < 0.05).ConclusionThis study demonstrated that RF was associated with temporary improvement in nasal congestion, nasal discharge, postnasal drip, olfactory disturbance, and overall sinonasal symptoms in CRS patients.