峰值鼻吸气流量在评估接受全组鼻窦内镜手术治疗的重度慢性鼻窦炎伴鼻息肉患者中的作用：一项前瞻性纵向研究。
Peak nasal inspiratory flow in the assessment of patients with severe chronic rhinosinusitis with nasal polyps treated with full house endoscopic sinus surgery: a prospective longitudinal study.
文献信息
| PMID | 42867645 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Paula Pérez-Chacón |
| 作者单位 | Department of Otorhinolaryngology-Head and Neck Surgery, Rhinology Unit, Río Hortega University Hospital, Valladolid, Spain. paulapchacon@gmail.com. |
| 期刊 | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery |
| SCI 分区 | Q1 |
| IF | 2.3 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 峰值鼻吸气流量（PNIF）是一种简单的鼻腔通畅度客观测量指标，但其在重度慢性鼻窦炎伴鼻息肉（CRSwNP）中的作用仍未充分明确。本研究评估了全组鼻窦内镜手术（ESS）后PNIF的纵向变化及其与鼻阻力计、声反射鼻测量和患者报告结局的关系。
方法： 前瞻性随访30例接受全组ESS的不受控CRSwNP成人患者，分别在基线以及1、3和6个月时进行。每次访视记录PNIF、参考压力150 Pa下的主动前鼻阻力计、声反射鼻测量、SNOT-22和视觉模拟量表（VAS）鼻塞评分。纳入健康对照组（n=30）进行横断面比较。纵向变化采用线性混合效应模型分析。
结果： PNIF随时间显著改善（F(3,115)=10.07，p<0.001），从术前125.6 L/min增至1个月时182.8 L/min、3个月时190.7 L/min和6个月时203.0 L/min。鼻阻力计阻力平行显著下降（F(3,83.7)=16.54，p<0.001），而声反射鼻测量参数未显示显著纵向变化。SNOT-22和VAS在术后明显改善（p<0.001）。基线时PNIF与鼻腔流量强相关，与总吸气阻力呈负相关（分别为r=0.732和r=-0.726，p<0.001），并且在术后早期访视时仍显著相关。与PROM的相关性呈时间依赖性。基线PNIF在CRSwNP中低于对照组，而6个月时的值超过对照组均值。
结论： PNIF是一种实用且临床有用的客观检查，用于评估重度CRSwNP患者。其纵向变化与鼻阻力计改善平行，并补充了全组ESS后基于PROM的评估。
英文摘要
BACKGROUND: Peak nasal inspiratory flow (PNIF) is a simple objective measure of nasal patency, but its role in severe chronic rhinosinusitis with nasal polyps (CRSwNP) remains insufficiently defined. This study evaluated the longitudinal behavior of PNIF after full-house endoscopic sinus surgery (ESS) and its relationship with rhinomanometry, acoustic rhinometry and patient-reported outcomes.
METHODOLOGY: Thirty adults with uncontrolled CRSwNP undergoing full-house ESS were prospectively followed at baseline and at 1, 3 and 6 months. PNIF, active anterior rhinomanometry at a reference pressure of 150 Pa, acoustic rhinometry, SNOT-22 and visual analogue scale (VAS) nasal obstruction scores were recorded at each visit. A healthy control group (n = 30) was included for cross-sectional comparison. Longitudinal changes were analyzed using linear mixed-effects models.
RESULTS: PNIF improved significantly over time (F(3,115) = 10.07, p < 0.001), increasing from 125.6 L/min preoperatively to 182.8 L/min at 1 month, 190.7 L/min at 3 months and 203.0 L/min at 6 months. Rhinomanometric resistance decreased significantly in parallel (F(3,83.7) = 16.54, p < 0.001), whereas acoustic rhinometry parameters did not show significant longitudinal change. SNOT-22 and VAS improved markedly after surgery ( p < 0.001). PNIF correlated strongly with nasal flow and inversely with total inspiratory resistance at baseline (r = 0.732 and r=-0.726, p < 0.001, respectively) and remained significantly associated at early postoperative visits. Correlations with PROMs were observed time-dependent. Baseline PNIF was lower in CRSwNP than in controls, while 6-month values exceeded the control mean.
CONCLUSIONS: PNIF is a practical and clinically useful objective test for the assessment of patients with severe CRSwNP. Its longitudinal behavior parallels rhinomanometric improvement and complements PROM-based assessment after Full House ESS.