Article record

沙特阿拉伯一家三级医疗中心鼻咽癌的流行病学与临床病理特征

Epidemiologic and clinicopathologic characteristics of nasopharyngeal carcinoma at a tertiary care center in Saudi Arabia.

临床研究鼻咽癌IF 1.8Q2

文献信息

PMID	42866337
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Abdullah O Alqthmi 查看其他 15 位作者 Renad H Alosaimi；Rawaf K Altowairqi；Sali A Sayed；Zainab A Alalqam；Ahmed A Bahaj；Haddad Hussain Alkaf；Jabir Alharbi；Sherif Abdelmonim；Hani Elkhatib；Faisal Albadainah；Maha Alidrisi；Mohammed Y Almaghrabi；Sahal Alzahrani；Ameen Alherabi；Mohammed A Alessa
作者单位	College of medicine, Umm Al-Qura University, Makkah, Saudi Arabia. 查看其他 8 条单位信息 College of pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.；Faculty of dentistry, Umm Al-Qura University, Makkah, Saudi Arabia.；College of medicine, University of Bisha, Bisha, Saudi Arabia.；Head and neck and skull base health center, King Abdullah Medical City, Makkah, Saudi Arabia.；Faculty of medicine, Ain Shams university, Cairo, Egypt.；Oncology Center, King Abdullah Medical City, Makkah, Saudi Arabia.；Radiation Oncology Department, Jeddah Oncology Center, King Abdullah Medical City, Makkah, Saudi Arabia.；Public Health Department, College of Health Sciences, The Saudi Electronic University, Jeddah, Saudi Arabia.
期刊	Annals of medicine and surgery (2012)
SCI 分区	Q2
IF	1.8
研究类型	临床研究 · 临床
所属专科	鼻咽癌

中文摘要

背景： 鼻咽癌（NPC）在全球范围内较为罕见；然而在沙特阿拉伯，它是最常见的头颈部恶性肿瘤，也是总体第17位常见恶性肿瘤。本研究旨在描述沙特阿拉伯一家三级医疗中心鼻咽癌患者的流行病学特征、临床特征及组织病理学亚型。
方法： 这项回顾性队列研究纳入2014年1月至2024年6月期间在一家三级转诊医院接受诊治的244例经组织学确诊的鼻咽癌（NPC）患者。从病历中提取人口学特征、临床表现、危险因素、组织病理学、Epstein-Barr病毒（EBV）状态及治疗方式，并使用SPSS 23版进行分析。
结果： 在244例患者中，75%为男性，25%为女性，受影响最多的年龄组为50-64岁（39%），其次为年龄≥65岁者（30%）。颈部肿块是最常见的就诊症状（31%）。组织病理学上，未分化癌（WHO III型）占主导（77%）。大多数患者确诊时已处于晚期，其中20%为III期，56%为IV期。吸烟、EBV感染及人口学特征与任何组织病理学亚型均无显著关联。同步放化疗（CCRT）是最常见的治疗方式（37%），其次是诱导化疗联合CCRT（31%）。
结论： 在沙特阿拉伯，鼻咽癌主要影响年龄较大的男性，颈部肿块是最常见的症状。吸烟和EBV感染与组织病理学亚型无显著关联。大多数病例为未分化癌（WHO III型）且确诊时已处于晚期，这凸显了在沙特阿拉伯持续开展监测和多中心研究的必要性。

英文摘要

BACKGROUND: Nasopharyngeal carcinoma (NPC) is rare globally; however, in Saudi Arabia, it is the most common head and neck cancer and the 17th most common cancer overall. This study aimed to describe the epidemiological characteristics, clinical features, and histopathological subtypes of NPC in patients at a tertiary care center in Saudi Arabia.
METHODS: This retrospective cohort study included 244 patients with histologically confirmed nasopharyngeal carcinoma (NPC) managed at a tertiary referral hospital between January 2014 and June 2024. Demographic characteristics, clinical presentation, risk factors, histopathology, Epstein-Barr virus (EBV) status, and treatment modalities were extracted from medical records and analyzed using SPSS version 23.
RESULTS: Among the 244 patients, 75% were male and 25% were female, with the most affected age groups being 50-64 years (39%), followed by those aged ≥65 years (30%). neck mass was the most common presenting symptom (31%). Histopathologically, undifferentiated carcinoma (WHO Type III) was predominant (77%). Most patients were diagnosed at an advanced stage, with 20% at stage III and 56% at stage IV. Smoking, EBV infection, and demographics showed no significant association with any histopathological subtype. Concurrent chemoradiotherapy (CCRT) was the most common treatment modality (37%) followed by induction chemotherapy with CCRT (31%).
CONCLUSION: In Saudi Arabia, NPC predominantly affects older males, with neck masses being the most frequent symptom. Smoking and EBV infection showed no significant association with histopathological subtypes. Most cases were undifferentiated carcinomas (WHO Type III) and diagnosed at advanced stages, highlighting the need for continued surveillance and multicenter studies in Saudi Arabia.