经口机器人手术与经口视频喉镜手术治疗口咽癌的纵向功能结局：一项回顾性单中心研究
Longitudinal Functional Outcomes After Transoral Robotic Surgery Versus Transoral Videolaryngoscopic Surgery for Oropharyngeal Cancer: A Retrospective Single-Center Study.
文献信息
| PMID | 42865578 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Kazufumi Obata |
| 作者单位 | Department of Otolaryngology-Head and Neck Surgery Tokai University School of Medicine Isehara Kanagawa Japan. |
| 期刊 | Laryngoscope investigative otolaryngology |
| SCI 分区 | Q2 |
| IF | 2.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 经口视频喉镜手术（TOVS）与经口机器人手术（TORS）治疗口咽癌的功能结局直接比较仍然有限。
方法： 这项回顾性单中心研究纳入35例接受TOVS的患者和13例接受TORS的患者。在术前以及术后1、3、6和12个月评估欧洲癌症研究与治疗组织（EORTC）QLQ-C30、EORTC QLQ-H&N35和Hyodo评分。线性混合效应模型（LMM）纳入时间、治疗、组别与时间的交互作用、T分期（Tis/T1/T2 vs. T3）、解剖亚部位（扁桃体 vs. 非扁桃体）、既往癌症导向治疗、同期颈淋巴结清扫、性别和年龄。
结果： 两组均显示术后短暂恶化，随后恢复。在预先设定的主要纵向LMM中，治疗对疼痛、张口、吞咽或Hyodo总分均无统计学显著主效应。
结论： 在本队列中，TOVS与TORS之间未检测到术后生活质量或吞咽恢复的统计学显著差异。该设计不能确立功能等效性；然而，当机器人系统不可用时，TOVS可能是一种实用的经口选择。
证据等级： 3。
英文摘要
OBJECTIVES: Direct comparisons of functional outcomes between transoral videolaryngoscopic surgery (TOVS) and transoral robotic surgery (TORS) for oropharyngeal cancer remain limited.
METHODS: This retrospective single-center study included 35 patients who underwent TOVS and 13 who underwent TORS. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30, EORTC QLQ-H&N35, and Hyodo scores were assessed preoperatively and at 1, 3, 6, and 12 months. A linear mixed-effects model (LMM) included time, treatment, the group-by-time interaction, T stage (Tis/T1/T2 vs. T3), anatomic subsite (Tonsil vs. not Tonsil), prior cancer-directed treatment, concurrent neck dissection, sex, and age.
RESULTS: Both groups showed transient postoperative deterioration followed by recovery. In the prespecified primary longitudinal LMM, treatment had no statistically significant main effect on pain, opening mouth, swallowing, or total Hyodo score.
CONCLUSION: In this cohort, no statistically significant differences in postoperative quality of life or swallowing recovery were detected between TOVS and TORS. This design does not establish functional equivalence; however, TOVS may be a practical transoral option when robotic systems are unavailable.
LEVEL OF EVIDENCE: 3.