肉毒毒素注射与类固醇注射治疗复发性喉接触性肉芽肿的比较
Comparison of Botulinum Toxin Versus Steroid Injection for Recurrent Laryngeal Contact Granuloma.
文献信息
| PMID | 42864247 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Shufang Zhang |
| 作者单位 | Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical University, Bengbu, 233000, China. Electronic address: f941908157@163.com. |
| 期刊 | Journal of voice : official journal of the Voice Foundation |
| SCI 分区 | Q1 |
| IF | 2.4 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 比较肉毒毒素注射与类固醇注射治疗复发性喉接触性肉芽肿患者的疗效。
方法： 对2021年8月至2026年4月期间接受肉毒毒素注射或类固醇注射治疗的44例复发性喉接触性肉芽肿患者的临床资料进行回顾性分析。患者被分为肉毒毒素注射组和类固醇注射组。比较两组的治愈率、复发率和治愈时间，以确定复发性病变患者的最佳治疗方法。
结果： 在复发性肉芽肿患者中，肉毒毒素注射组显示出更高的治愈率（90%）和更低的复发率（0%），而类固醇注射组为治愈率76.47%、复发率11.54%，尽管差异无统计学意义（P > 0.05）。类固醇注射组的治愈时间显著长于肉毒毒素注射组（P < 0.01）。
结论： 在复发性喉接触性肉芽肿患者中，与类固醇注射相比，肉毒毒素注射与更短的治愈时间相关。肉毒毒素注射是复发性肉芽肿的有效治疗方法。
英文摘要
OBJECTIVES: To compare the efficacy of botulinum toxin injection versus steroid injection in the treatment of patients with recurrent laryngeal contact granuloma.
METHODS: A retrospective analysis was conducted on clinical data from 44 patients with recurrent laryngeal contact granuloma who received either botulinum toxin injection or steroid injection between August 2021 and April 2026. Patients were divided into a botulinum toxin injection group and a steroid injection group. The cure rate, recurrence rate, and time to cure were compared between the two groups to determine the optimal treatment for patients with recurrent lesions.
RESULTS: In patients with recurrent granulomas, the botulinum toxin injection group demonstrated a higher cure rate (90%) and a lower recurrence rate (0%) compared with the steroid injection group (cure rate: 76.47%; recurrence rate: 11.54%), although the differences were not statistically significant (P > 0.05). The time to cure in the steroid injection group was significantly longer than that in the botulinum toxin injection group (P < 0.01).
CONCLUSION: In patients with recurrent laryngeal contact granuloma, botulinum toxin injection was associated with a shorter time to cure compared with steroid injection. Botulinum toxin injection is an effective treatment for recurrent granulomas.