Article record

特发性急性单侧听觉前庭病的神经耳科学与MRI相关性

Neurotologic and MRI Correlates of Idiopathic Acute Unilateral Audiovestibulopathy.

临床研究耳科IF 2.3Q2

文献信息

PMID	42860639
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Keun-Tae Kim 查看其他 7 位作者 Arim Pak；Jueun Kim；Sun-Uk Lee；Euyhyun Park；Moon-Jung Hwang；Byungjun Kim；Ji-Soo Kim
作者单位	Department of Neurology, Korea University Medical Center, Seoul, South Korea. 查看其他 6 条单位信息 Department of Radiology, Anam Hospital, Korea University College of Medicine, Seoul, South Korea.；Neurotology and Neuro-Ophthalmology Laboratory, Korea University Medical Center, Seoul, South Korea.；Department of Otorhinolaryngology-Head and Neck Surgery, Korea University Medical Center, Seoul, South Korea.；Department of Radiology and Advanced Medical Imaging Institute, Korea University Anam Hospital, Korea University College of Medicine, Seoul, South Korea.；Dizziness Center, Clinical Neuroscience Center, Seoul National University Bundang Hospital, Seongnam, South Korea.；Department of Neurology, Seoul National University College of Medicine, Seoul, South Korea.
期刊	The Laryngoscope
SCI 分区	Q2
IF	2.3
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

目的： 尽管MRI有助于检测特发性急性单侧听觉前庭病（iAUAV），但影像学与神经耳科学发现之间的关系仍不明确。
方法： 我们回顾性审查了2018年3月至2025年9月期间在韩国一家三级医院诊断为iAUAV的患者的医疗记录。纳入分析的数据包括神经耳科学资料以及重T2加权三维液体衰减反转恢复（FLAIR）序列的影像学数据。
结果： 共有84例iAUAV患者纳入分析。44例患者（52%）发现MRI阳性，表现为前庭（n=31）、水平半规管（HC，n=27）、后半规管（PC，n=24）和前半规管（AC，n=22）以及耳蜗基底转（n=15）、顶转（n=13）和中转（n=10）的高信号强度。多变量logistic回归分析显示，MRI阳性与后半规管（PC）的前庭眼反射（VOR）增益呈负相关（p=0.028）。水平半规管（HC）和后半规管（PC）的VOR增益与前庭（q=0.021）及各半规管（q=0.025）的归一化信号强度比呈负相关。
结论： 52%的iAUAV患者在平扫前3D-FLAIR图像上显示阳性，并与后半规管（PC）的前庭功能缺陷密切相关。观察到的MRI与神经耳科学发现之间的相关性可能有助于iAUAV的诊断和鉴别，并为其作为急性听觉前庭病常见病因的潜在病理生理机制提供见解。

英文摘要

OBJECTIVE: Although MRI can aid in detecting idiopathic acute unilateral audiovestibulopathy (iAUAV), the relationship between imaging and neurotologic findings remains unclear.
METHODS: We retrospectively reviewed the medical records of patients diagnosed with iAUAV at a tertiary hospital in South Korea between March 2018 and September 2025. Neurotologic and imaging data on heavily T2-weighted 3D fluid-attenuated inversion recovery (FLAIR) sequences were included for analysis.
RESULTS: Eighty-four patients with iAUAV were included in the analysis. MRI-positivity was found in 44 patients (52%), with high signal intensities in the vestibule (n = 31), horizontal (HC, n = 27), posterior (PC, n = 24), and anterior canals (AC, n = 22), as well as basal (n = 15), apical (n = 13), and middle turns of the cochlea (n = 10). Multivariable logistic regression analysis showed that MRI positivity was negatively associated with vestibulo-ocular reflex (VOR) gain for the PC (p = 0.028). The VOR gains for the HC and PC were negatively correlated with the normalized signal intensity ratios of the vestibule (q = 0.021) and each semicircular canal (q = 0.025).
CONCLUSION: 52% of patients with iAUAV showed positivity on precontrast 3D-FLAIR images, showing a strong association with vestibular deficits in the PC. The observed correlation between MRI and neurotologic findings may facilitate the diagnosis and differentiation of iAUAV and provide insight into its underlying pathophysiology as a frequent cause of acute audiovestibulopathy.