Article record

睡眠呼吸障碍与睡眠碎片化与心房颤动风险的关系：一项系统综述与荟萃分析。

Sleep-Disordered Breathing and Sleep Fragmentation in Relation to Atrial Fibrillation Risk: A Systematic Review and Meta-Analysis.

综述 Meta咽喉科IF 1.8Q3

文献信息

PMID	42859517
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Ermias Sori 查看其他 9 位作者 Hassaan Abid；Zartasha；Walquiria Pedra；Anuoluwapo Odewabi；Ibrahim Layi Salau；Vaghani Jillkumar；Ali Hyder；Mohammed Mutar；Yasar Sattar
作者单位	Baylor Scott and White the Heart Hospital Denton Texas USA. 查看其他 9 条单位信息 Indiana University School of Medicine Indianapolis Indiana USA.；Islamic International Medical College Rawalpindi Pakistan.；Centro University De Valenca Valença Rio de Janeiro Brazil.；University of Ibadan Ibadan Nigeria.；Federal Medical Center, Baze University Abuja Nigeria.；Government Medical College Surat Surat India.；Quetta Institute of Medical Science Quetta Pakistan.；University of Baghdad College of Medicine Baghdad Iraq.；West Virginia University Morgantown West Virginia USA.
期刊	Journal of arrhythmia
SCI 分区	Q3
IF	1.8
研究类型	综述 Meta · 临床
所属专科	咽喉科

中文摘要

背景： 心房颤动（AF）是全球最常见的心律失常之一。本研究旨在评估睡眠呼吸障碍（SDB，主要采用呼吸暂停低通气指数AHI评估）与AF风险之间的关联，并额外分析睡眠碎片化参数，如入睡后觉醒时间（WASO）和觉醒指数（AI）。
方法： 本系统综述与荟萃分析遵循Cochrane手册建议和PRISMA指南，方案已在PROSPERO注册（编号127490）。纳入评估睡眠障碍与AF的随机对照试验（RCT）和观察性队列研究。检索MEDLINE、Cochrane Library和Scopus，时间自建库至2026年2月。提取的数据包括研究特征、人口学资料、心血管危险因素和睡眠指标。结局为 incident 和 recurrent AF。采用随机效应模型。
结果： 共纳入21项队列研究（611,898名参与者）。SDB与 incident AF风险增加相关（RR 1.67，95% CI 1.41-1.97；I² = 66.5%），贝叶斯估计结果一致。剂量-反应关系显示，AHI每升高一个单位，AF风险增加2%。对于AF复发，11项研究（n = 1810）显示显著关联（RR 1.55，95% CI 1.40-1.72；I² = 0%），贝叶斯分析支持该结果。
结论： 睡眠障碍与 incident 和 recurrent AF均显著相关，可能是可改变的危险因素。

英文摘要

BACKGROUND: Atrial fibrillation (AF) is one of the most prevalent cardiac arrhythmias worldwide. This study aimed to evaluate the association between sleep-disordered breathing (SDB), primarily assessed using the apnea-hypopnea index (AHI), and AF risk, with additional analysis of sleep fragmentation parameters such as wake after sleep onset (WASO) and arousal index (AI).
METHODS: This systematic review and meta-analysis followed Cochrane Handbook recommendations and PRISMA guidelines, with protocol registration in PROSPERO (No. 127490). Randomized controlled trials (RCTs) and observational cohort studies assessing sleep disturbances and AF were included. MEDLINE, Cochrane Library, and Scopus were searched from inception to February 2026. Extracted data included study characteristics, demographics, cardiovascular risk factors, and sleep metrics. Outcomes were incident and recurrent AF. A random-effects model was applied.
RESULTS: Twenty-one cohort studies (611,898 participants) were included. SDB was associated with increased incident AF risk (RR 1.67, 95% CI 1.41-1.97; I 2 = 66.5%), with consistent Bayesian estimates. A dose-response relationship showed a 2% increase in AF risk per unit rise in AHI. For AF recurrence, 11 studies (n = 1810) demonstrated a significant association (RR 1.55, 95% CI 1.40-1.72; I 2 = 0%), supported by Bayesian analysis.
CONCLUSION: Sleep disturbances are significantly associated with both incident and recurrent AF and may represent modifiable risk factors.