Article record

高危监测人群中阻塞性睡眠呼吸暂停与胰腺癌的关联：CAPS和PCYST队列研究

Association of obstructive sleep apnea with pancreatic cancer in high-risk patients under surveillance in CAPS and PCYST cohorts.

临床研究咽喉科IF 3.8Q2

文献信息

PMID	42859088
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Hassan Sinan 查看其他 13 位作者 Emy Abou Sleiman；Amanda L Blackford；Takahiro Shinozuka；Dimitri Melki；Jad Saab；Michael Romanos；Kylie Ning；Michel Almardini；Andrea Castellino；Eun Ji Shin；Elham Afghani；Marcia Irene Canto；Michael Goggins
作者单位	Departments of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, United States of America. 查看其他 3 条单位信息 Departments of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, United States of America.；Departments of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, United States of America.；Departments of Pathology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, United States of America; Departments of Oncology, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, United States of America; Departments of Medicine, The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University, Baltimore, MD, United States of America. Electronic address: mgoggins@jhmi.edu.
期刊	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
SCI 分区	Q2
IF	3.8
研究类型	临床研究 · 临床
所属专科	咽喉科

中文摘要

背景： 阻塞性睡眠呼吸暂停（OSA）与癌症发病率和死亡率增加有关。我们假设OSA可能是接受胰腺癌监测的患者肿瘤进展的危险因素。
方法： 对两个约翰霍普金斯医院接受胰腺监测的队列进行回顾性病历审查；纳入胰腺癌筛查研究（CAPS）中具有家族性/遗传性风险的患者，以及PCYST研究中偶然发现胰腺囊肿的患者。按OSA状态比较进展为胰腺导管腺癌（PDAC）和肿瘤进展（PDAC、高级别不典型增生或胰腺神经内分泌肿瘤）的时间，并校正协变量。
结果： 在CAPS队列的893例患者中，174例（19.5%）在监测前或监测期间被诊断为OSA；在PCYST队列的1585例患者中，376例（23.7%）被诊断为OSA。在合并队列中，OSA与进展为PDAC的风险增加相关（未校正HR：3.12，95% CI：[1.82, 5.34]，p < 0.001）。OSA还与男性、较高的BMI、脂肪肝、脂肪胰、糖尿病和吸烟史相关（所有p < 0.01）。在校正协变量后，OSA仍与PDAC风险相关（校正HR：2.56 [1.44, 4.55]，p = 0.001）。与肿瘤进展相关的因素包括OSA（校正HR：1.93 [1.25, 2.97]，p = 0.003）、年龄增长（每5岁校正HR：1.14 [1.05, 1.24]，p = 0.003）、脂肪肝（校正HR：1.76 [1.19, 2.60]，p = 0.005）和糖尿病（校正HR：1.77 [1.16, 2.71]，p = 0.008）。
结论： 因家族性/遗传性风险和/或偶然发现的胰腺囊肿而接受胰腺监测的患者，如果被诊断为OSA，则发生胰腺癌的可能性更大。

英文摘要

BACKGROUND: Obstructive sleep apnea (OSA) has been linked with increased cancer incidence and mortality. We hypothesized that OSA may be a risk factor for neoplastic progression among patients undergoing pancreatic cancer surveillance.
METHODS: Retrospective medical record review of two Johns Hopkins Hospital cohorts undergoing pancreas surveillance; patients with familial/genetic risk enrolled in the Cancer of the Pancreas Screening (CAPS) study and patients with incidentally detected pancreatic cysts, enrolled in the PCYST study. Time-to-progression to pancreatic ductal adenocarcinoma (PDAC) and neoplastic progression (either PDAC, high-grade dysplasia or pancreatic neuroendocrine tumor) were compared by OSA status, adjusting for covariates.
RESULTS: OSA was diagnosed prior to or during surveillance in 174 (19.5%) of 893 patients in CAPS and 376 (23.7%) of 1585 patients in the PCYST cohort. In the combined cohorts, OSA was associated with increased risk of progression to PDAC (unadjusted HR: 3.12, 95% CI: [1.82, 5.34], p < 0.001). OSA was also associated with male sex, higher BMI, fatty liver, fatty pancreas, diabetes, and history of smoking (all p < 0.01). After covariate adjustment, OSA remained associated with PDAC risk (adjusted HR: 2.56 [1.44, 4.55], p = 0.001). Factors associated with neoplastic progression included OSA (adjusted HR: 1.93 [1.25, 2.97], p = 0.003), increasing age (age-per 5-years adjusted HR: 1.14 [1.05, 1.24], p = 0.003), fatty liver (adjusted HR: 1.76 [1.19, 2.60], p = 0.005), and diabetes (adjusted HR: 1.77 [1.16, 2.71], p = 0.008).
CONCLUSIONS: Patients undergoing pancreatic surveillance for their familial/genetic risk and/or incidentally detected pancreatic cysts have a greater likelihood of developing pancreatic cancer if they've been diagnosed with OSA.