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新的CRS控制测试:EUFOREA的开发和验证

New CRS control tests: development and validation by EUFOREA.

临床研究鼻科IF 4.9Q1

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中文摘要

背景: 测量慢性鼻窦炎(CRS)的控制情况在临床评估中很重要。我们开发并验证了2种用于评估CRS控制情况的新测试,即6项CRS控制测试(CCT)和14项CRS患者控制测试(CPCT),并研究了它们与现有工具的相关性。
方法: 在7个国家19个中心的1,102名CRS患者中进行了一项国际调查,使用包含新开发的CCT和CPCT、CRS严重程度和控制的VAS评分、EPOS控制测试(EPOSCT)、鼻-鼻窦结局测试22(SNOT-22)和患者整体评估工具(PGAT)的问卷。我们评估了聚合效度和区分效度、内部一致性和跨文化效度。此外,我们进行了项目反应理论(IRT)分析,并确定了CCT和CPCT的截断点。对伴有和不伴有鼻息肉的CRS患者进行了亚组分析。
结果: CCT(0-24)和CPCT(0-56)均与SNOT-22和PGAT高度相关。所有其他比较均观察到中等相关性。两种测试均显示出良好的内部一致性、区分效度和跨文化效度。我们建议CCT≤15表示未控制,16-19部分控制,≥20控制良好。对于CPCT,我们建议≥22表示未控制,13-21表示部分控制,≤12表示控制良好。
结论: 简短的CCT和较长的CPCT是新的CRS控制测试,与现有工具显示出中等至高度相关性。两种工具均表现出良好的心理测量学特性,因此可推荐用于临床实践和研究。

英文摘要

BACKGROUND: Measuring control in Chronic Rhinosinusitis (CRS) is important in clinical evaluation. We developed and validated 2 new tests for the evaluation of control in CRS, the 6-item CRS Control Test (CCT) and the 14-item CRS Patient Control Test (CPCT) and investigated their correlations with existing tools.
METHODS: An international survey was conducted in 1,102 CRS patients in 19 centres in 7 countries using a questionnaire including the newly developed CCT and CPCT, VAS scores for CRS severity and control, the EPOS control test (EPOSCT), the Sino-Nasal Outcome Test 22 (SNOT-22) and the Patient Global Assessment Tool (PGAT). We evaluated convergent and discriminative validity, internal consistency and cross-cultural validity. Furthermore, we performed an Item Response Theory (IRT) analysis and determined cut-off points for CCT and CPCT. Sub-analyses were performed for CRS patients with and without nasal polyps.
RESULTS: Both CCT (0-24) and CPCT (0-56) demonstrated a high correlation with SNOT-22 and the PGAT. Moderate correlations were observed for all other comparisons. Both tests showed good internal consistency, discriminative validity and cross-cultural validity. We propose for CCT ≤15 to indicate uncontrolled, 16-19 partially controlled, and ≥20 well controlled disease. For the CPCT we propose ≥22 for uncontrolled, 13-21 for partially controlled and ≤12 for well controlled disease.
CONCLUSION: The brief CCT and the longer CPCT are new CRS control tests that show moderate to high correlations with existing tools. Both instruments demonstrated good psychometric properties and therefore can be recommended for use in clinical practice and research.