Article record

血液系统恶性肿瘤中侵袭性真菌性鼻窦炎与侵袭性真菌性肺炎的人口学、临床及真菌学差异

Demographic, Clinical, and Mycologic Differences Between Invasive Fungal Sinusitis and Pneumonia in Hematologic Malignancy.

临床研究鼻科IF 3.5Q2

文献信息

PMID	42856922
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Simran Gupta 查看其他 12 位作者 Tejas S Athni；Esther Arbona-Haddad；Inia Perez Villa；Alexis Liakos；Alexandra Tong；Maria Shehata；Carolyn Strauch；Muneerah M Aleissa；Alice Z Maxfield；Regan W Bergmark；Victor Kovac；Amy C Sherman
作者单位	Division of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA. 查看其他 6 条单位信息 Dana-Farber Cancer Institute, Boston, Massachusetts, USA.；Harvard Medical School, Boston, Massachusetts, USA.；Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.；College of Pharmacy, Department of Pharmacy Practice, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.；Department of Otolaryngology, Brigham and Women's Hospital, Boston, Massachusetts, USA.；Division of Infectious Diseases, Massachusetts General Hospital, Boston, MA, USA.
期刊	Open forum infectious diseases
SCI 分区	Q2
IF	3.5
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

在132例患有血液系统恶性肿瘤和侵袭性真菌病的患者中，与侵袭性真菌性肺炎相比，侵袭性真菌性鼻窦炎与更高的播散率、更低的生物标志物敏感性、更多样的真菌病原体以及更高的慢性鼻窦炎和鼻窦缺损发生率相关。这些发现提示二者是不同的临床综合征，具有不同的危险因素和诊断考量。

英文摘要

Among 132 people with hematologic malignancies and invasive fungal disease, invasive fungal sinusitis was associated with greater dissemination, lower biomarker sensitivity, more diverse fungal pathogens, and higher rates of chronic rhinosinusitis and sinonasal defects than invasive fungal pneumonia. These findings suggest distinct clinical syndromes with different risk factors and diagnostic considerations.