睡眠障碍与妊娠期糖尿病亚型之间的关联：一项前瞻性队列研究
Association between sleep impairment and gestational diabetes mellitus subtypes: A prospective cohort study.
文献信息
| PMID | 42853357 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Niannian Chen |
| 作者单位 | The Born in Guangzhou Cohort Study Group, Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China. |
| 期刊 | Sleep & breathing = Schlaf & Atmung |
| SCI 分区 | Q3 |
| IF | 2.8 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
目的： 探讨睡眠障碍与妊娠期糖尿病（GDM）及其亚型之间的关联。
方法： 纳入来自广州出生队列研究的29,183名孕妇。收集了睡眠质量、睡眠时长和睡眠呼吸障碍（SDB）症状的信息。GDM通过75克、2小时口服葡萄糖耐量试验和医疗记录进行诊断。GDM被分为三种亚型。采用泊松回归模型进行分析。
结果： 共有4713名（16.2%）被诊断为GDM。睡眠质量差、夜间睡眠时间短和SDB症状与GDM风险增加相关，调整后的RR分别为1.07（95% CI 1.01, 1.13）、1.12（95% CI 1.04, 1.22）和1.19（95% CI 1.10, 1.30）。夜间睡眠时间短和SDB症状还与空腹血糖受损合并糖耐量受损（IFG+IGT）亚型的较高风险相关（RR分别为1.55，95% CI 1.22, 1.96；RR 1.80，95% CI 1.42, 2.29）。夜间睡眠时间长与单纯糖耐量受损（i-IGT）亚型的较低风险相关（RR 0.89，95% CI 0.80, 0.99）。
结论： 我们的研究结果表明，有睡眠障碍的孕妇更可能发展为GDM，尤其是IFG+IGT亚型。减少睡眠障碍，特别是SDB症状，可能是预防GDM的干预目标。
英文摘要
AIMS: To examine the association of sleep impairment with gestational diabetes mellitus (GDM) and its subtypes.
METHODS: 29,183 pregnant women from the Born in Guangzhou Cohort Study were included. Information on sleep quality, sleep duration and sleep-disordered breathing (SDB) symptoms were collected. GDM was diagnosed using a 75 g, 2h oral glucose tolerance test and medical records. GDM was categorised into three subtypes. Poisson regression models were performed.
RESULTS: In total, 4713 (16.2%) were diagnosed with GDM. Poor sleep quality, short nighttime sleep duration and SDB symptoms were associated with increased risks of GDM, with adjusted RR of 1.07 (95% CI 1.01, 1.13), 1.12 (95% CI 1.04, 1.22) and 1.19 (95% CI 1.10, 1.30), respectively. Short nighttime sleep duration and SDB symptoms were also associated with higher risks of the subtype of combined impaired fasting glucose and impaired glucose tolerance (IFG + IGT) (RR 1.55, 95% CI 1.22, 1.96; RR 1.80, 95% CI 1.42, 2.29, respectively). Long nighttime sleep duration was associated with lower risks of the subtype of isolated impaired glucose tolerance (i-IGT) (RR 0.89, 95% CI 0.80, 0.99).
CONCLUSIONS: Our findings indicate that pregnant women with sleep impairment are more likely to develop GDM, especially the IFG + IGT subtype. Reducing sleep impairment, particularly SDB symptoms, may be a target for intervention to prevent GDM.