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早期农业暴露与阿尔茨海默病神经病理负荷之间的关联。

Association between early-life farming exposure and Alzheimer's disease neuropathological burden.

临床研究耳科IF 14.3Q1

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中文摘要

背景: 农业人群可能承受不成比例的不良暴露,这些暴露会影响阿尔茨海默病(AD),然而农业数据很少与具有特征明确的AD神经病理的队列相关联。早期生活暴露是否与AD神经病理相关尚有限。
方法: 纳入来自两个阿尔茨海默病研究中心的脑捐赠者(N = 1035;1986-2018年间)。使用美国人口普查记录识别具有早期农业暴露(出生至17岁)者,并将其与AD神经病理评估一起检查。
结果: 早期农业暴露(约占捐赠者的17%)与AD神经病理负荷的几率增加60%相关(比值比 = 1.60,95%置信区间:1.09-2.35),校正了年龄、性别和死亡年份。
结论: 研究结果表明,生命早期接触农业与AD神经病理水平升高有关。需要更深入的职业和居住表型分析,以识别潜在的多种重叠风险通路,其中可能包括对化学毒物的累积和敏感生命阶段暴露、听力损失以及心理社会危害。

英文摘要

BACKGROUND: Farming populations may face a disproportionate share of adverse exposures influencing Alzheimer's disease (AD), yet farming data are rarely connected to cohorts with characterized AD neuropathology. Whether early-life exposure is related to AD neuropathology is limited.
METHOD: Brain donors from two Alzheimer's Disease Research Centers (N = 1035; between 1986-2018) were included. US Census records were used to identify those with early-life farming exposure (birth to 17 years old) and examined alongside AD neuropathology assessments.
RESULT: Early-life farming exposure (≈ 17% of donors) was associated with 60% higher odds of AD neuropathological burden (odds ratio = 1.60, 95% confidence interval: 1.09-2.35) adjusting for age, sex, and year of death.
CONCLUSION: Findings suggest exposure to farming early in life is linked to increased levels of AD neuropathology. Deeper occupational and residential phenotyping is needed to identify the potential multiple, overlapping risk pathways, which may include cumulative and sensitive life stage exposure to chemical toxicants, hearing loss, and psychosocial hazards.