一例接受手术及姑息性放疗的犬喉横纹肌肉瘤

文献信息

中文摘要

背景： 原发性喉肿瘤在犬中罕见，可能导致严重的气道阻塞。由于临床症状的严重性以及手术治疗相关的挑战，常选择安乐死。方法：一只3岁已绝育雌性意大利灵缇犬因喉部肿块不完全手术切除后喉横纹肌肉瘤复发而被转诊。术后15天发现残留肿瘤进展，犬被转诊进行进一步评估。计算机断层扫描显示右侧喉咽壁内有一软组织肿块，呈中心对比增强。主人拒绝再次进行积极手术，遂实施放射治疗。总放射剂量为24 Gy，分4次每周照射。结果：治疗后临床症状改善，放射治疗开始后168天观察到肿瘤缩小。在放射治疗开始后742天的最后一次随访中，犬保持临床稳定，肿瘤持续缩小。结论：本病例提示，有限的手术处理后继以放射治疗可能是一种可行的治疗选择，并可能为患有喉横纹肌肉瘤的犬带来良好的长期临床结局。关键临床信息：有限的手术切除后继以放射治疗可能是犬喉横纹肌肉瘤的一种治疗选择。

英文摘要

Primary laryngeal tumors are rare in dogs and may cause severe airway obstruction. Euthanasia is frequently elected because of the severity of clinical signs and the challenges associated with surgical treatment. A 3-year-old spayed female Italian greyhound dog was referred because of recurrence of a laryngeal rhabdomyosarcoma following incomplete surgical removal of a laryngeal mass. Residual tumor progression was identified 15 d after surgery and the dog was referred for further evaluation. Computed tomography revealed a soft-tissue mass within the right laryngopharyngeal wall, showing central contrast enhancement. The owner declined additional aggressive surgery and radiation therapy was delivered. A total radiation dose of 24 Gy was delivered in 4 weekly fractions. Clinical signs improved following treatment and tumor reduction was observed 168 d after initiation of radiation therapy. The dog remained clinically stable with sustained tumor reduction at the last follow-up, 742 d after initiation of radiation therapy. This case suggests that limited surgical management followed by radiation therapy may represent a viable treatment option and may lead to favorable long-term clinical outcomes in dogs with laryngeal rhabdomyosarcoma. Key clinical message: Limited surgical removal followed by radiation therapy may represent a treatment option for dogs with laryngeal rhabdomyosarcoma.