伴有和不伴有吸气肌无力的COVID-19后个体的肺功能、功能能力、嗓音和睡眠。
Pulmonary Function, Functional Capacity, Voice, and Sleep in Post-COVID-19 Individuals With and Without Inspiratory Muscle Weakness.
文献信息
| PMID | 42844033 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Marthina Carbone Dos Santos |
| 作者单位 | Graduate Program in Human Communication Disorders, Federal University of Santa Maria, Av. nº 1000 - Camobi, Santa Maria, RS 97105-900. Electronic address: marthinacarbone11@gmail.com. |
| 期刊 | Journal of voice : official journal of the Voice Foundation |
| SCI 分区 | Q1 |
| IF | 2.4 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 比较伴有和不伴有吸气肌无力的COVID-19后个体的肺功能、功能能力、嗓音和睡眠，并探讨嗓音偏差、呼吸肌力量、肺功能、功能能力和睡眠参数之间的关联。
方法： 横断面研究，纳入28名COVID-19后成人，分为伴有吸气肌无力组（n=14）和不伴有吸气肌无力组（n=14）（最大吸气压-MIP-<预测值的70%）。肺功能通过肺量计评估；呼吸肌力量通过最大呼吸压评估；吸气肌耐力通过60% MIP的负荷评估；功能能力通过六分钟步行试验评估；疲劳通过疲劳严重程度量表和Chalder疲劳量表评估；嗓音通过嗓音障碍指数（VHI）、嗓音疲劳指数（VFI）和最大发声时间（MPT）评估；睡眠通过失眠严重程度指数、Epworth嗜睡量表和夜间血氧测定评估。
结果： 伴有吸气肌无力的个体表现出更高的疲劳患病率（P=0.02），更高的VHI生理领域得分（P=0.008）和VHI总分（P=0.01），在分类分析时嗓音功能影响（VHI的功能领域）发生率更高（P=0.02），更高的VFI得分（因子一P=0.008；因子二P=0.002；因子三P=0.002；总分P=0.03），以及在分析连续变量和分类变量时/音素/s/和/z/的MPT更低（P=0.02；P=0.03）。观察到VFI总分与MIP之间呈负相关（r=-0.467；P=0.01），以及VFI与MIP预测值百分比之间呈负相关（r=-0.396；P=0.03），表明吸气肌力量水平越低，嗓音疲劳越严重。
结论： COVID-19后个体的吸气肌无力与更严重的疲劳和更差的嗓音结局相关，强调了呼吸评估在理解呼吸与嗓音相互作用中的重要性。
英文摘要
OBJECTIVE: To compare pulmonary function, functional capacity, voice, and sleep in post-COVID-19 individuals with and without inspiratory muscle weakness, as well as to investigate the association between vocal deviations, respiratory muscle strength, pulmonary function, functional capacity, and sleep parameters.
METHODS: Cross-sectional study with 28 post-COVID-19 adults, distributed into groups with (n = 14) and without (n = 14) inspiratory muscle weakness (maximal inspiratory pressure -MIP-<70% of the predicted value). Pulmonary function was assessed by spirometry; respiratory muscle strength by maximal respiratory pressures; inspiratory muscle endurance with a load of 60% of MIP; functional capacity by the Six-Minute Walk Test; and fatigue by the Fatigue Severity Scale and Chalder Fatigue Scale; voice was assessed using the Vocal Handicap Index (VHI), Vocal Fatigue Index (VFI), and Maximum Phonation Time (MPT); and sleep was assessed using the Insomnia Severity Index, Epworth Sleepiness Scale, and nocturnal oximetry.
RESULTS: Individuals with inspiratory muscle weakness presented a higher prevalence of fatigue (P = 0.02), higher scores in the physical domain (P = 0.008) and in the total VHI score (P = 0.01), greater occurrence of vocal functional impact (functional domain of the VHI) when analyzed in a categorized way (P = 0.02), higher scores in the VFI (factor one P = 0.008; factor two P = 0.002; factor three P = 0.002; total score P = 0.03), and lower MPT of the phonemes /s/ and /z/ (P = 0.02; P = 0.03) when analyzing continuous and categorical variables. A negative correlation was observed between the total VFI score and MIP (r = -0.467; P = 0.01), as well as between the VFI and the percentage of predicted MIP (r = -0.396; P = 0.03), indicating that lower levels of inspiratory muscle strength were associated with greater vocal fatigue.
CONCLUSION: Inspiratory muscle weakness in post-COVID-19 individuals is associated with greater fatigue and poorer vocal outcomes, underscoring the importance of respiratory assessment in understanding the interaction between breathing and voice.