儿童期疾病与磨牙-切牙矿化不全相关吗？——一项观察性研究的结果。
Are childhood diseases associated with Molar-Incisor Hypomineralization? - Results from an observational study.
文献信息
| PMID | 42841997 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Elena Pernegger |
| 作者单位 | Department of Conservative Dentistry, Periodontology and Digital Dentistry, LMU University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany. |
| 期刊 | Clinical oral investigations |
| SCI 分区 | Q1 |
| IF | 3.9 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 本观察性研究旨在探讨报告的儿童期疾病及婴儿早期用药与后期出现磨牙-切牙矿化不全（MIH）之间的潜在关联。
材料与方法： 作为一项前瞻性设计的流行病学研究的一部分，对5,418名8至10岁的巴伐利亚儿童进行了龋齿（WHO标准）和MIH（EAPD标准）检查。此外，每名儿童都收到一份由其父母填写的问卷。共回收1,315份问卷，包含关于儿童期疾病、用药和社会经济状况的完整信息。构建了边际零膨胀负二项回归模型。
结果： 共有263名儿童（20.0%）被诊断为MIH，平均有3.3（±2.0）颗受MIH影响的牙齿。在支气管炎（IRR 1.25，95% CI 1.07-1.46）、中耳炎（aOR 1.91，95% CI 1.30-2.80）、眼部疾病、过敏、言语障碍、蠕虫感染和心脏疾病的情况下，发现与MIH的存在显著相关。此外，还证实了抗生素使用与MIH之间的显著关联（生命第一年：IRR 1.45，95% CI 1.15-1.83；aOR 1.86，95% CI 1.13-3.05/生命第二年：IRR 1.35，95% CI 1.05-1.77；aOR 1.36，95% CI 1.05-1.77）。
结论： 这些关联大多与低病例数有关，因此不能解释所记录的20.0%的MIH患病率。因此，儿童期疾病和抗生素使用可能并非单独促成MIH的发展。
临床相关性： MIH的病因仍不清楚，表明需要进一步研究。
英文摘要
OBJECTIVE: This observational study aimed to investigate the potential association between reported childhood diseases and medications during early infancy and the later appearance of molar incisor hypomineralization (MIH).
MATERIALS AND METHODS: As part of a prospectively designed epidemiological study, 5,418 Bavarian children aged 8 to 10 were examined for the presence of caries (WHO standard) and MIH (EAPD criteria). In addition, each child received a questionnaire to be completed by their parents. A total of 1,315 questionnaires were returned, containing complete information on childhood diseases, medication and socioeconomic status. Marginalized zero-inflated negative binomial regression models were constructed.
RESULTS: A total of 263 children (20.0%) were diagnosed with MIH, with a mean of 3.3 (± 2.0) MIH-affected teeth. In cases of bronchitis (IRR 1.25 with 95% CI 1.07-1.46), otitis media (aOR 1.91 with 95% CI 1.30-2.80), eye diseases, allergies, speech disorders, worm infections and cardiac diseases, significant associations were found for the presence of MIH. In addition, a significant association between antibiotic use and MIH was confirmed (first year of life: IRR 1.45 with 95% CI 1.15-1.83; aOR 1.86 with 95% CI 1.13-3.05/second year of life: IRR 1.35 with 95% CI 1.05-1.77; aOR 1.36 with 95% CI 1.05-1.77).
CONCLUSIONS: The associations were mostly associated with low case numbers and accordingly cannot explain the documented MIH prevalence of 20.0%. Therefore, childhood diseases and antibiotic use probably do not solely contribute to MIH development.
CLINICAL RELEVANCE: MIH aetiology remains unclear, indicating a need for further research.