妊娠剧吐中的前庭症状负担：与偏头痛和晕动病的量表比较
Vestibular symptom burden in hyperemesis gravidarum: A scale-based comparison with migraine and motion sickness.
文献信息
| PMID | 42841802 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Emel Uğur |
| 作者单位 | Department of Audiometry, Acibadem Mehmet Ali Aydinlar University Vocational School of Health Sciences, Istanbul, Turkiye. |
| 期刊 | Journal of vestibular research : equilibrium & orientation |
| SCI 分区 | Q3 |
| IF | 3.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 晕动病（MS）、视觉诱发晕动病（VIMS）、妊娠剧吐（HG）和偏头痛共享一系列症状，包括恶心、呕吐、头晕和运动敏感性增高。这些共同点提示可能存在涉及前庭和中枢神经系统机制的共同神经生理学基础。本研究旨在从专门的前庭视角评估HG严重程度、MS易感性、VIMS易感性和偏头痛相关症状负担之间的关联。
方法： 这项横断面研究纳入了1010名有妊娠史的女性。数据通过一份全面的在线问卷收集。使用了以下评估工具：妊娠期呕吐专用量化表（PUQE-24）、晕动病易感性问卷（MSSQ）、视觉诱发晕动病易感性问卷（VIMSSQ）、偏头痛残疾评估量表（MIDAS）和头痛影响测试-6（HIT-6）。采用非参数检验进行组间比较和相关性分析。
结果： 根据PUQE-24评分，参与者被分为轻度（44.5%）、中度（46.8%）或重度（8.7%）。MSSQ、VIMSSQ和HIT-6评分在HG严重程度组间差异显著（p < .05），而MIDAS评分则无显著差异（p = .055）。与报告轻度症状的参与者相比，具有重度HG症状的参与者表现出更高的晕动病和视觉诱发晕动病易感性，以及更大的头痛影响。
结论： 更大的HG严重程度伴随着对MS和VIMS的更高易感性，以及更大的偏头痛相关症状负担，尽管观察到的关联在幅度上通常有限。这些发现提示前庭敏感性在妊娠相关恶心和呕吐中可能发挥作用。然而，需要进一步纳入客观前庭评估的研究来阐明其临床和生理学相关性。
英文摘要
PurposeMotion sickness (MS), visually induced motion sickness (VIMS), hyperemesis gravidarum (HG), and migraine share a spectrum of symptoms, including nausea, vomiting, dizziness, and heightened motion sensitivity. These commonalities suggest a potential shared neurophysiological basis involving vestibular and central nervous system mechanisms. This study aimed to evaluate the association between HG severity, MS susceptibility, VIMS susceptibility, and migraine-related symptom burden from a specialized vestibular perspective.MethodsThis cross-sectional study included 1010 women with a history of pregnancy. Data were collected via a comprehensive online questionnaire. The following assessment tools were utilized: Pregnancy-Unique Quantification of Emesis (PUQE-24), Motion Sickness Susceptibility Questionnaire (MSSQ), Visually Induced Motion Sickness Susceptibility Questionnaire (VIMSSQ), Migraine Disability Assessment Scale (MIDAS), and Headache Impact Test-6 (HIT-6). Nonparametric tests were used for group comparisons and correlations.ResultsParticipants were categorized as mild (44.5%), moderate (46.8%), or severe (8.7%) based on PUQE-24 scores. MSSQ, VIMSSQ, and HIT-6 scores differed significantly across HG severity groups (p < .05), whereas MIDAS scores did not (p = .055). Participants with severe HG symptoms demonstrated higher motion sickness and visually induced motion sickness susceptibility, as well as greater headache impact, compared with those reporting mild symptoms.ConclusionsGreater HG severity was accompanied by greater susceptibility to MS and VIMS, as well as a greater migraine-related symptom burden, although the observed associations were generally limited in magnitude. These findings suggest a possible role of vestibular sensitivity in pregnancy-related nausea and vomiting. However, further studies incorporating objective vestibular assessments are needed to clarify its clinical and physiological relevance.