健康人脑内压后皮层与海马之间的结构连接：一项弥散张量纤维束成像研究。

文献信息

中文摘要

压后皮层（RSC）和海马是参与空间导航的重要区域，它们将前庭信息整合到空间表征中。尽管这些区域之间的功能相互作用已被证实，但目前缺乏关于人脑中RSC与海马之间结构连接的证据。本研究旨在使用弥散张量成像（DTI）纤维束成像，重建并表征健康成人中RSC与海马之间的纤维束成像衍生通路。方法：招募了30名健康成人。参考矢状面和轴状面，在RSC中定义种子感兴趣区（ROI），并在轴状面上将目标ROI放置在海马内。分析了结构特征，包括各向异性分数、平均弥散率和纤维束体积。结果：在所有参与者中均双侧识别出纤维束成像衍生的RSC-海马通路。结论：本研究表征了健康人脑中纤维束成像衍生的RSC-海马通路。我们的发现为RSC-海马结构连接提供了见解，并提示了这些区域在空间信息处理中相互作用的潜在结构基础。

英文摘要

The retrosplenial cortex (RSC) and hippocampus are important regions involved in spatial navigation by integrating vestibular information into spatial representations. Although functional interactions between these regions have been demonstrated, there is currently a lack of evidence regarding the structural connectivity between the RSC and hippocampus in the human brain. This study aimed to reconstruct and characterize a tractography-derived pathway between the RSC and hippocampus in healthy adults using diffusion tensor imaging (DTI) tractography. Methods Thirty healthy adults were recruited. The seed region of interest (ROI) was defined in the RSC with reference to both sagittal and axial planes, and the target ROI was placed within the hippocampus on the axial plane. The structural characteristics, including fractional anisotropy, mean diffusivity, and tract volume were analyzed. Results A tractography-derived RSC-hippocampal pathway was identified bilaterally in all participants. Conclusion This study characterized a tractography-derived RSC-hippocampal pathway in the healthy human brain. Our findings provide insight into RSC-hippocampal structural connectivity and suggest a potential structural substrate for interactions between these regions in spatial information processing.