先天性鼻泪管阻塞与上气道病理之间的关联：来自大型多中心队列的见解。
Association between congenital nasolacrimal duct obstruction and upper airway pathology: insights from a large multicenter cohort.
文献信息
| PMID | 42838337 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Yossi Eshel |
| 作者单位 | Department of Ophthalmology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel. |
| 期刊 | Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus |
| SCI 分区 | Q3 |
| IF | 1.4 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
目的： 利用大型多中心电子健康记录网络的数据，评估CNLDO与腺样体肥大、腺样体切除术、阻塞性睡眠呼吸暂停（OSA）及扁桃体肥大之间的关联。
方法： 这项回顾性、多中心队列研究使用了TriNetX（一个大型全球电子健康记录网络）的数据。共纳入16,007名患有CNLDO的儿童，并与同等数量的倾向评分匹配的无CNLDO对照进行比较。应用严格的排除标准，排除患有先天性畸形、变形、染色体异常、分娩并发症、母体或围产期并发症或眼外伤的患者。主要结局是腺样体肥大、腺样体切除术、OSA和扁桃体肥大的5年发病率。
结果： 与匹配对照相比，患有CNLDO的儿童腺样体肥大（1.45% vs 1.15%；HR = 1.28；95% CI，1.05-1.55；P = 0.013）、腺样体切除术（0.96% vs 0.62%；HR = 1.57；95% CI，1.22-2.02；P = 0.0004）和OSA（1.40% vs 1.11%；HR = 1.27；95% CI，1.04-1.55；P = 0.017）的发生率显著更高。扁桃体肥大显示出阳性趋势（2.78% vs 2.46%；HR = 1.14；95% CI，1.00-1.31；P = 0.051）。
结论： 发现CNLDO与腺样体肥大、腺样体切除术和阻塞性睡眠呼吸暂停之间存在显著关联。这种关联可能意味着上气道病理直接促进CNLDO的发展，或者这两种情况具有共同的易感性并独立发生。
英文摘要
PURPOSE: To evaluate the association between CNLDO and adenoid hypertrophy, adenoidectomy, obstructive sleep apnea (OSA), and tonsillar hypertrophy, using data from a large multicenter electronic health record network.
METHODS: This retrospective, multicenter cohort study used data from TriNetX, a large global electronic health record network. A total of 16,007 children with CNLDO were included and compared with an equal number of propensity score-matched controls without CNLDO. Strict exclusion criteria were applied to omit patients with congenital malformations, deformations, chromosomal abnormalities, complications of labor, maternal or perinatal complications, or ocular trauma. The primary outcomes were the 5-year incidence rates of adenoid hypertrophy, adenoidectomy, OSA, and tonsillar hypertrophy.
RESULTS: Children with CNLDO had significantly higher rates of adenoid hypertrophy (1.45% vs 1.15%; HR = 1.28; 95% CI, 1.05-1.55; P = 0.013), adenoidectomy (0.96% vs 0.62%; HR = 1.57; 95% CI, 1.22-2.02; P = 0.0004), and OSA (1.40% vs 1.11%; HR = 1.27; 95% CI, 1.04-1.55; P = 0.017) compared with matched controls. Tonsillar hypertrophy showed a positive trend (2.78% vs 2.46%; HR = 1.14; 95% CI, 1.00-1.31; P = 0.051).
CONCLUSIONS: A significant association was found between CNLDO and adenoid hypertrophy, adenoidectomy, and obstructive sleep apnea. This association may imply that upper airway pathology contributes directly to the development of CNLDO, or that both conditions share common predispositions and arise independently.