生物材料与生物疗法在鼓膜再生中的应用：系统综述与展望。
Biomaterials and Biological Therapies in Tympanic Membrane Regeneration: Systematic Review and Perspective.
文献信息
| PMID | 42836543 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Hannah Daoudi |
| 作者单位 | Université Paris Cité, Institut Pasteur, AP-HP, Inserm, Fondation Pour l'Audition, Institut de l'Audition, IHU re-Connect F-75012, Technologies and Gene Therapy for Deafness, Paris, France. |
| 期刊 | Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery |
| SCI 分区 | Q1 |
| IF | 2.9 |
| 研究类型 | 综述 Meta · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的： 慢性鼓膜穿孔通常需要手术修复，最常见的是通过鼓室成形术。尽管有效，但这些手术涉及麻醉、费用较高，并且可能并非总能获得。本综述的目的是探索能够促进鼓膜再生并可能减少手术需求的生物材料和生物疗法。
数据来源： PubMed 和 Google Scholar，时间范围为1958年9月至2025年12月。
综述方法： 按照PRISMA指南，对关于用于鼓膜修复的生物材料或生物疗法的临床研究进行了系统综述。同时，进行了不限日期的叙述性文献综述，以整合关于鼓膜修复的实验和转化数据。采用综合方法将实验和临床领域的研究结果置于背景中。
结果： 在识别出的573篇摘要中，83项研究被纳入系统综述：21项关于生物活性生物材料（透明质酸、丝素蛋白），62项关于生物疗法（生长因子、血小板浓缩物、血清）。
结论： 本综述表明，关于该主题的临床研究有限且难以开展。血小板浓缩物衍生物在促进慢性鼓膜穿孔闭合方面显示出有希望的结果，而其他生物材料和生物疗法的证据则较为有限，部分原因是自体材料在临床环境中通常更容易研究。
英文摘要
OBJECTIVE: Chronic tympanic membrane perforations generally require surgical repair, most often via tympanoplasty. While effective, these procedures involve anesthesia, carry significant costs, and may not always be accessible. The objective of this review is to explore biomaterials and biological therapies that could promote tympanic membrane regeneration and potentially reduce the need for surgery.
DATA SOURCES: PubMed and Google Scholar between September 1958 and December 2025.
REVIEW METHODS: A PRISMA-guided systematic review of clinical studies about biomaterials or biological therapies for tympanic membrane repair was conducted. In parallel, a narrative literature review was performed, without date restrictions, to integrate experimental and translational data about tympanic membrane repair. A synthesis was used to contextualize findings across experimental and clinical domains.
RESULTS: Of 573 abstracts identified, 83 studies were included in the systematic review: 21 about bioactive biomaterials (hyaluronic acid, silk fibroin) and 62 about biological therapies (Growth factors, platelet concentrates, serum).
CONCLUSION: This review shows that clinical studies on this subject are limited and challenging to conduct. Platelet concentrates derivates have shown promising results for promoting closure of chronic tympanic membrane perforations, while evidence for other biomaterials and biological therapies is more limited, partly because autologous materials are generally easier to study in clinical settings.