Article record

扩展高频听力影响大脑对语音的皮层反应幅度

Extended high frequency hearing influences cortical response amplitudes to speech.

临床研究耳科IF 6.6Q1

文献信息

PMID	42833461
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Rodrigo Donoso-San Martín 查看其他 14 位作者 Stefan Fink；Konrad Dapper；Etienne Gaudrain；Deniz Başkent；Sarah Verhulst；Csaba Harasztosi；Wibke Singer；Manuel S Malmierca；Markus Siegel；Ernst Dalhoff；Stephan M Wolpert；Christoph Braun；Lukas Rüttiger；Marlies Knipper
作者单位	Department of Otolaryngology, Head and Neck, University of Tübingen, 72076 Tübingen, Germany; Departamento de Neurociencia, Facultad de Medicina, Universidad de Chile, and Centro Interdisciplinario de Neurociencia UC, Pontificia Universidad Católica de Chile, Santiago, Chile. 查看其他 10 条单位信息 Department of Otolaryngology, Head and Neck, University of Tübingen, 72076 Tübingen, Germany.；Department of Otolaryngology, Head and Neck, University of Tübingen, 72076 Tübingen, Germany; Department of Psychology, University of Western Ontario, London, Ontario, Canada.；Lyon Neuroscience Research Center, Université Claude Bernard Lyon 1, CNRS UMR5292, Inserm U1028, University of Lyon 1, Center Hospitalier Le Vinatier -Bâtiment 462-Neurocampus, 95 boulevard Pinel Lyon, France.；Department of Otorhinolaryngology, University Medical Center Groningen (UMCG), Hanzeplein 1, BB21, 9700RB Groningen, The Netherlands; Research School of Behavioral and Cognitive Neuroscience, Graduate School of Medical Sciences, University of Groningen, Groningen, the Netherlands.；Department of Information Technology - Hearing Technology @Waves, Ghent University, Ghent, Belgium.；Cognitive and Auditory Neuroscience Laboratory (CANELab). The Medical School & Institute of Neuroscience of Castilla y León (INCYL), Universidad de Salamanca. Spain.；Department of Neural Dynamics and Magnetoencephalography, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany; MEG Center, University of Tübingen, Tübingen, Germany; Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany; MEG Center, University of Tübingen, Tübingen, Germany; Center for Bionic Intelligence Tübingen Stuttgart (BITS), Tübingen, Germany; German Center for Mental Health (DZPG), Tübingen, Germany.；Department of Neural Dynamics and Magnetoencephalography, Hertie Institute for Clinical Brain Research, University of Tübingen, Germany; MEG Center, University of Tübingen, Tübingen, Germany; Centre for Integrative Neuroscience, University of Tübingen, Tübingen, Germany; MEG Center, University of Tübingen, Tübingen, Germany; Center for Bionic Intelligence Tübingen Stuttgart (BITS), Tübingen, Germany; CIMeC, Center for Mind/Brain Sciences, University of Trento, Corso Bettini 31, 38068 Rovereto, Italy.；Department of Otolaryngology, Head and Neck, University of Tübingen, 72076 Tübingen, Germany. Electronic address: Lukas.ruettiger@Uni-tuebingen.de.；Department of Otolaryngology, Head and Neck, University of Tübingen, 72076 Tübingen, Germany. Electronic address: marlies.knipper@uni-tuebingen.de.
期刊	NeuroImage
SCI 分区	Q1
IF	6.6
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

背景： 由于年轻人能听到高达20 kHz的声音，扩展高频听力（EHF；8 kHz以上）的丧失是年龄相关性听力损失的标志，通常从生命早期就开始进展。然而，这种缺陷常常未被发现，因为常规临床听力测试和大多数助听器目前大多限于8 kHz。EHF听力已与噪声中言语感知缺陷和自我报告的听力相关联。然而，EHF听力如何影响言语可懂度仍不清楚。方法：在此，我们在一个频率标记言语范式中使用脑磁图（MEG）记录神经磁性脑反应，该范式旨在探测注意力和记忆依赖性言语处理和识别的层级水平。结果：与EHF听力较好的受试者相比，EHF听力受损个体的左右大脑半球的听觉诱发皮层磁场（AEF）反应均显著降低。在EHF听力保留的年轻人（19-29岁）中，未观察到随年龄增长的左半球AEF逐渐增强。这与更强的听觉脑干反应（ABR）相关，反映了刺激开始时更好的神经同步听觉反应。相比之下，EHF听力受损年轻人的左半球优势增强与较低的ABR相关。结论：我们的发现表明，通过影响刺激起始同步对听觉皮层振荡的相位锁定，8 kHz以上的声能有助于言语的可懂度。总之，这些结果强调需要重新考虑听力学评估和助听器设计中的EHF听力。

英文摘要

Since young adults hear sounds up to 20 kHz, the loss of extended high-frequency hearing (EHF; above 8 kHz) is a hallmark of age-related hearing loss, often progressing from early lifetime. However, this deficit frequently goes undetected because routine clinical hearing tests and most hearing aids are currently mostly limited to 8 kHz. EHF hearing has been linked to deficits in speech perception in noise and to self-reported hearing. However, it remains elusive how EHF hearing influences speech intelligibility. Here we recorded neuromagnetic brain responses using magnetoencephalography (MEG) within a frequency-tagging speech paradigm designed to probe hierarchical levels of attention and memory-dependent speech processing and recognition. Auditory evoked cortical magnetic field (AEF) responses were significantly reduced in both left and right brain hemispheres in individuals with impaired EHF hearing compared to those subjects with better EHF hearing. A gradual reinforcement of left-hemispheric AEF seen over age was not observed in young adults (19-29 y) with preserved EHF hearing. This was linked to stronger auditory brainstem responses (ABR), reflecting better neural synchronized auditory responses at stimulus onset. The reinforced left hemispheric dominance in young adults with impaired EHF hearing, in contrast, was linked to lower ABRs. Our findings suggest that through its impact on stimulus-onset synchrony to phase locking of oscillations in the auditory cortex, sound energy above 8 kHz contributes to the intelligibility of speech. Together, the results highlight the need to reconsider EHF hearing in both audiological assessment and hearing-aid design.