在II型牙槽窝即刻种植的前庭窝洞治疗中，向生物活性屏障技术添加心包膜的影响：一项随机临床试验。

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中文摘要

本研究旨在比较单独使用或联合心包膜使用的可缓慢吸收的皮质层状骨膜（CLBM）与富集骨移植物的疗效。该治疗旨在确定在采用VST处理的II型牙槽窝中即刻牙种植体植入后，颊侧骨板厚度、颊侧骨板高度和软组织厚度的改善情况。三十名具有II型牙槽窝的参与者被随机分配到两个实验组。A组在应用粘性骨后接受CLBM的即刻种植体。B组在应用CLBM和粘性骨后接受心包膜覆盖。所有参与者在六个月的随访期内接受了定期的临床和影像学评估。在6个月时，B组在冠状位（p值=0.04）和中点（p值=0.02）的颊侧骨厚度显示出统计学显著增加。此外，A组的颊侧骨板高度表现出高度显著的下降（p值=0.002）。软组织厚度显示A组软组织值非显著减少（p值=0.36），而B组显著增加（p值=<0.001）。将心包膜与皮质层状骨膜和自体富纤维蛋白骨移植物整合显示出协同效应，最终实现了更优越的牙槽骨保存。该研究已在ClinicalTrials.gov注册，编号为NCT06867848。

英文摘要

This investigation aimed to compare the efficacy of a slowly resorbable cortical laminar bone membrane (CLBM), used either in isolation or in combination with a pericardium membrane, alongside an enriched bone graft. The treatment was to ascertain improvements in buccal plate thickness, buccal plate height, and soft-tissue thickness after immediate dental implant placement into Type II alveolar sockets managed with VST. Thirty participants with type II alveolar sockets were randomly assigned to two experimental cohorts. They received immediate implants with CLBM after sticky bone application in group A. In group B, they received coverage with a pericardium membrane after application of CLBM and sticky bone. All participants underwent periodic clinical and radiographic assessments over a six-month follow-up duration. At 6 months, Group B showed a statistically significant augmentation in buccal bone thickness at the coronal (p-value = 0.04) and midpoint (p-value = 0.02). Furthermore, Group A manifested a highly significant decrease in buccal plate height (p-value = 0.002). Soft tissue thickness shows a non-significant reduction in soft tissue values in group A(p-value = 0.36) and a significant increase in group B (p- value = < 0.001). The integration of a pericardial membrane with a cortical lamellar bone membrane and an autologous fibrin-rich bone graft demonstrated a synergistic effect, culminating in superior alveolar bone preservation. The study was registered at ClinicalTrials.gov NCT06867848.