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病毒性脑膜炎和脑炎中感音神经性听力损失的发生情况

Occurrence of Sensorineural Hearing Loss in Viral Meningitis and Encephalitis.

临床研究耳科IF 3.8Q2

文献信息

PMID42831535
原文在 PubMed 查看原文 ↗
发表日期2026
作者Elisa Skovgaard Jensen
查看其他 9 位作者

Andreas Vestergaard Jensen；Per Cayé-Thomasen；Pelle Trier Petersen；Birgitte Rønde Hansen；Nichlas Hovmand；Rannvá Winther；Jonas Bruun Kjærsgaard；Malene Kirchmann；Christian T Brandt

作者单位Department of Otorhinolaryngology, Nordsjællands Hospital, University of Copenhagen, Hillerød, Denmark.
查看其他 7 条单位信息

Department of Otorhinolaryngology Head and Neck Surgery and Audiology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark.；Department of Infectious Diseases, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark.；Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.；Department of Infectious Diseases, Hvidovre Hospital, University of Copenhagen, Hvidovre, Denmark.；Department of Infectious Diseases, Aalborg University Hospital, University of Aalborg, Aalborg, Denmark.；Department of Otorhinolaryngology Head and Neck Surgery and Audiology, Aalborg University Hospital, University of Aalborg, Aalborg, Denmark.；Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.

期刊Journal of medical virology
SCI 分区Q2
IF3.8
研究类型临床研究 · 临床
所属专科耳科

中文摘要

背景： 病毒性神经感染中的听力损失研究甚少。本研究旨在阐明病毒性脑膜炎和脑炎中是否会发生听力损失。方法：对成年病毒性脑膜炎和脑炎患者在入院当天以及出院后30-60天进行OAE（耳声发射）测量。频率分为低频（1、1.5、2 kHz）、中频（3、4、5 kHz）、中高频（6、7、8 kHz）和高频（9、10 kHz）。对41例病毒性脑膜炎患者和8例脑炎患者进行了OAE测量。结果：6例病毒性脑膜炎患者（15%）在一个或多个频率类别中出现了>5 dB的下降。12例患者（29%）OAE水平暂时下降超过5 dB，23例患者（54%）在入院和随访之间OAE水平无变化。我们发现不同病毒性脑膜炎病原体之间从入院到随访的OAE水平无显著差异。在病毒性脑炎中，5例单纯疱疹病毒患者中有3例在所有频率上均出现OAE水平下降。水痘带状疱疹脑炎与OAE水平变化无关。结论：病毒性脑膜炎和单纯疱疹性脑炎与感音神经性听力损失的发生相关。

英文摘要

Hearing loss in viral neuroinfections is poorly investigated. The present study aimed to clarify if hearing loss can develop in viral meningitis and encephalitis. An OAE (oto-acoustic emission) was measured in adult patients with viral meningitis and encephalitis on the day of admission and 30-60 days after discharge. Frequencies were categorized as Low (1, 1.5, 2 kHz), Mid (3, 4, 5 kHz), Mid-high (6, 7, 8 kHz), and High (9, 10 kHz). An OAE was measured in 41 patients with viral meningitis and 8 patients with encephalitis. Six patients with viral meningitis (15%) experienced a decrease of > 5 dB in one or more frequency categories. Twelve patients (29%) had a temporary decrease in OAE levels of more than 5 dB and 23 patients (54%) had no change in OAE levels between admission and follow-up. We found no significant differences in OAE levels from admission to follow-up between viral meningitis pathogens. In viral encephalitis, herpes simplex virus was associated with a decrease in OAE levels in all frequencies in 3 of 5 patients. Varicella zoster encephalitis was not associated with changes in OAE levels. Viral meningitis and herpes simplex encephalitis is associated with development of a sensorineural hearing loss.