掌纹过度线性与持续性特应性皮炎轨迹及高过敏风险相关：日本环境与儿童研究的山梨辅助研究
Palmar hyperlinearity is associated with persistent atopic dermatitis trajectory with high allergic risk: The yamanashi adjunct study of the Japan environment and Children's study.
文献信息
| PMID | 42830251 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Reiji Kojima |
| 作者单位 | Department of Epidemiology, School of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan. Electronic address: kojimar@yamanashi.ac.jp. |
| 期刊 | Allergology international : official journal of the Japanese Society of Allergology |
| SCI 分区 | Q1 |
| IF | 7.3 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 掌纹过度线性（PH）是Hanifin和Rajka提出的特应性皮炎（AD）次要诊断标准，并与丝聚蛋白（FLG）基因的功能丧失变异相关。尽管FLG变异与AD的长期病程相关，但关于PH与AD轨迹之间关系的证据有限。我们研究了PH与儿童长期AD结局之间的关联。
方法： 我们分析了日本环境与儿童研究山梨辅助研究中1769名儿童的数据。PH由对AD轨迹不知情的儿科过敏专科医生评估，并通过基于人工智能（AI）的评估进行判断。AD轨迹基于6个月至6岁之间的八次评估，采用纵向潜在类别分析进行识别。使用多项逻辑回归检验PH与AD轨迹之间的关联，以从不/不频繁组作为参照。
结果： 34名儿童（1.9%）被识别出PH，10名（0.6%）被识别出基于AI的PH。共识别出四种AD轨迹：持续性（8.5%）、早发性（16.7%）、晚发性（10.3%）和从不/不频繁（64.6%）。PH与持续性AD显著相关（调整后OR 3.60，95% CI 1.49-8.67），但与早发性或晚发性表型无关。基于AI的PH也观察到类似发现。持续性AD还与6岁时的过敏症状（食物过敏、哮喘、过敏性鼻炎）以及8岁时的过敏致敏相关。
结论： PH与以更持续病程为特征的AD表型相关。
英文摘要
BACKGROUND: Palmar hyperlinearity (PH) is a minor diagnostic criterion for atopic dermatitis (AD) proposed by Hanifin and Rajka and is associated with loss-of-function variants in the filaggrin (FLG) gene. Although FLG variants are linked to the long-term course of AD, evidence on the relationship between PH and AD trajectories is limited. We investigated the association between PH and long-term AD outcomes in children.
METHODS: We analyzed data from 1769 children in the Yamanashi Adjunct Study of the Japan Environment and Children's Study. PH was assessed by pediatric allergy specialists blinded to AD trajectories and by an artificial intelligence (AI)-based assessment. AD trajectories were identified using longitudinal latent class analysis based on eight assessments between 6 months and 6 years of age. Associations between PH and AD trajectories were examined using multinomial logistic regression with the never/infrequent group as reference.
RESULTS: PH was identified in 34 children (1.9%) and AI-based PH in 10 (0.6%). Four AD trajectories were identified: persistent (8.5%), early-onset (16.7%), late-onset (10.3%), and never/infrequent (64.6%). PH was significantly associated with persistent AD (adjusted OR 3.60, 95% CI 1.49-8.67) but not with early- or late-onset phenotypes. Similar findings were observed for AI-based PH. Persistent AD was also associated with allergic symptoms (food allergy, asthma, allergic rhinitis) at age 6 and allergic sensitization at age 8.
CONCLUSIONS: PH was associated with an AD phenotype characterized by a more persistent disease course.