新发帕金森病中与自我感知言语障碍相关的因素：一项国际数据库的回顾性研究。
Factors associated with self- perceived speech impairment in de novo Parkinson's disease: a retrospective study of an international database.
文献信息
| PMID | 42827767 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Zoë Thijs |
| 作者单位 | Department of Communication Disorders and Occupational Therapy, University of Arkansas, Fayetteville, AR, United States. |
| 期刊 | Frontiers in aging neuroscience |
| SCI 分区 | Q1 |
| IF | 5.6 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
引言： 帕金森病（PwPD）患者可能在疾病早期就出现言语变化，但他们如何感知这些变化尚不清楚。此外，特别是在新发帕金森病中，言语、认知和吞咽之间的关系尚未明确。因此，本研究旨在确定新发帕金森病中自我感知言语障碍、临床医生感知言语障碍、认知障碍和吞咽障碍之间的关联。
方法： 数据来自帕金森病进展标志物计划。我们纳入了1072名新发帕金森病患者的基线访视数据。采用有序逻辑回归分析确定哪些临床指标与自我感知言语障碍相关。
结果： 有序逻辑回归发现，自我感知言语障碍与临床医生感知言语障碍（Wald χ2[3] = 44.039，p < 0.001）、自我报告的吞咽障碍（Wald χ2[3] = 61.863，p < 0.001）、认知障碍（Wald χ2[4] = 32.293，p < 0.001）以及男性性别（Wald χ2[1] = 11.520，p < 0.001）显著相关。
结论： 这项初步工作显示了自我感知与临床医生感知言语障碍、吞咽障碍和认知障碍之间的潜在关系，证明了自我感知言语障碍的多维性质。需要采用更广泛评估方法的更多研究来进一步阐明新发帕金森病中的这些关系。
英文摘要
INTRODUCTION: People with Parkinson's disease (PwPD) may experience speech changes early in the disease process, yet it is unclear how they perceive them. Moreover, in de novo PD specifically, the relationship between speech, cognition, and swallowing is not well-established. Therefore, this study aimed to determine the association between self-perceived speech impairment, clinician-perceived speech impairment, cognitive impairment, and swallowing impairment in de novo PD.
METHODS: Data were obtained from the Parkinson's Progressive Markers Initiative. We included baseline visit data from 1072 de novo PwPD. An ordinal logistic regression was performed to determine what clinical measures were associated with self-perceived speech impairment.
RESULTS: The ordinal logistic regression found that self-perceived speech impairments were significantly associated with clinician-perceived speech impairment (Wald χ2[3] = 44.039, p < 0.001), self-reported swallowing impairment (Wald χ2[3] = 61.863, p < 0.001), cognitive impairment (Wald χ2[4] = 32.293, p < 0.001), and being male (Wald χ2[1] = 11.520, p < 0.001).
CONCLUSION: This preliminary work showed potential relationships between self-perceived and clinician-perceived speech impairment, swallowing impairment, and cognitive impairment, demonstrating the multidimensional nature of self-perceived speech impairment. More research using more extensive assessment methods is needed to further elucidate these relationships in de novo PD.