关于平衡耳蜗植入电流聚焦策略中的兴奋模式锐度、响度及对言语感知的潜在影响。
On Balancing Sharpness of Excitation Patterns, Loudness, and Potential Effects on Speech Perception with Cochlear-Implant Current-Focussing Strategies.
文献信息
| PMID | 42827232 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | François Guérit |
| 作者单位 | Cambridge Hearing Group, MRC Cognition and Brain Sciences Unit, University of Cambridge, 15 Chaucer Road, Cambridge, CB2 7EF, UK. Francois.Guerit@mrc-cbu.cam.ac.uk. |
| 期刊 | Journal of the Association for Research in Otolaryngology : JARO |
| SCI 分区 | Q1 |
| IF | 3.1 |
| 研究类型 | 基础研究 · 基础／转化 |
| 所属专科 | 耳科 |
中文摘要
目的： 耳蜗植入（CI）使用者在噪声条件下理解言语存在困难。这长期以来被归因于通道交互：特定神经元不仅对来自最近电极的电刺激产生反应，还对来自距离更远电极的刺激敏感。将刺激电压塑造成非常尖锐的分布（例如使用三极刺激而非更常见的单极刺激）已被提出作为解决方案，但仅取得有限成功。我们认为这是由于几个因素：相邻CI通道包络与语音信号之间的强相关性，为足够响度而需要募集足够神经元的必要性，以及在响度较大时，单极和尖锐刺激在距离给定刺激电极至少3-4个电极的位置处输出电压的相似性。方法：我们描述了一种“Hilltop”方法，可有效降低距离给定电极3-4个电极以外的电压，同时保持与单极刺激相同的位置音高感知。我们在人类CI使用者（N=7名男性，9名女性）中通过心理物理学方法评估了该方法，并进行了计算建模。结果：基于计算建模和电荷求和的心理物理学测量，我们表明单极刺激和Hilltop刺激之间的电压差异在螺旋神经节神经元水平上持续存在。结论：这些结果值得使用更复杂的多通道刺激进行研究。我们还描述了该策略可能的局限性，包括在某些参与者中存在相反有效极性的旁瓣，并提出了减轻其影响的方法。
英文摘要
PURPOSE: Cochlear implant (CI) users struggle to understand speech under noisy conditions. This has long been attributed to channel interactions: a given neuron not only responds to electrical stimulation from the closest electrode but also is sensitive to stimulation from electrodes located further away. Shaping the stimulation voltage into a very sharp profile (e.g. using tripolar instead of the more common monopolar stimulation) has been proposed as a solution, only with limited success. We argue this is due to several factors: the strong correlation between envelopes of adjacent CI channels with speech sounds, the necessity to recruit enough neurons for sufficient loudness, and, at loud levels, the similarity between monopolar and sharp stimulation output voltages at locations that are at least 3-4 electrodes away from a given stimulation electrode.
METHODS: We describe a "Hilltop" method to effectively reduce the voltage more than 3-4 electrodes away from a given electrode, while keeping the same percept of place pitch as with monopolar stimulation. We assess this method psychophysically in human CI users (N = 7 males, 9 females) and with computational modelling.
RESULTS: Based on computational modelling and on psychophysical measures of charge summation, we show that the voltage difference between monopolar and Hilltop stimulation persists at the level of the spiral ganglion neurons.
CONCLUSIONS: The results warrant investigations with more complex, multichannel stimuli. We also describe possible limitations of this strategy, including the presence of sidelobes of opposite effective polarity in some participants, and suggest ways to mitigate their effects.