过敏性三联征青少年中血清白蛋白与血嗜酸性粒细胞的关系：一项来自NHANES的横断面研究。
Relationship between serum albumin and blood eosinophils in adolescents with allergic triad: A Cross-sectional study from NHANES.
文献信息
| PMID | 42826276 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Yanyan Zhang |
| 作者单位 | Neonatology Department, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, China. |
| 期刊 | Medicine |
| SCI 分区 | Q2 |
| IF | 2.1 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 虽然血清白蛋白与嗜酸性粒细胞之间的关联已在成人哮喘中进行过研究，但其在任何儿童特应性三联征——哮喘、过敏性鼻炎或特应性皮炎——中的作用仍不清楚。我们使用一个为期2年的国家健康与营养调查（NHANES）周期数据，评估了表现为任何特应性三联征的青少年中血清白蛋白与血嗜酸性粒细胞计数之间的关联。
方法： 我们分析了2005-2006年NHANES周期中658名年龄12-18岁、患有任何特应性三联征疾病的参与者的数据。采用多变量线性回归模型评估血清白蛋白水平与血嗜酸性粒细胞计数（BEOC）之间的潜在关联。应用趋势检验、平滑曲线拟合和阈值效应模型来确认这种关系，并进行分层分析以评估其在不同亚组中的一致性。
结果： 在完全调整模型中观察到血清白蛋白与BEOC之间存在显著的负相关（β = -0.08 × 10³细胞/µL，95% CI：-0.15，-0.01，P = .018）。此外，曲线拟合和阈值效应分析证实血清白蛋白与BEOC之间存在非线性关系，阈值和饱和效应的拐点为4.4 g/dL，超过该点后关联减弱。分层分析证实了其在关键亚群中的稳健性。
结论： 我们的研究确定了患有任何特应性三联征的青少年中血清白蛋白水平与BEOC之间存在非线性关联，呈现L形关系。这些发现强调白蛋白作为过敏性炎症中营养-免疫相互作用的潜在生物标志物，并支持在高风险儿科人群中进行有针对性的营养策略。
英文摘要
While the association between serum albumin and eosinophils has been investigated in adult asthma, its role in any pediatric atopic triad - asthma, allergic rhinitis, or atopic dermatitis - remains unclear. We assessed the association between serum albumin and blood eosinophil counts in adolescents presenting with any atopic triad, using data from a 2-year National Health and Nutrition Examination Survey (NHANES) cycle. We analyzed data from 658 participants aged 12-18 years with any atopic triad condition from the 2005-2006 NHANES cycle. Multivariate linear regression models were employed to assess the potential association between serum albumin levels and blood eosinophil counts (BEOC). Trend tests, smooth curve fitting, and threshold effect models were applied to confirm this relationship, and stratified analyses were conducted to assess its consistency across subgroups. A significant negative association was observed between serum albumin and BEOC in the fully adjusted model (β = -0.08 × 103 cells/µL, 95% CI: -0.15, -0.01, P = .018). Moreover, curve fitting and threshold effect analyses confirmed a nonlinear relationship between serum albumin and BEOC, with an inflection point for threshold and saturation effects of 4.4 g/dL, beyond which the association attenuated. Stratified analyses confirmed robustness across key subpopulations. Our study identified a nonlinear association between serum albumin levels and BEOC in adolescents with any atopic triad, exhibiting an L-shaped relationship. These findings highlight albumin as a potential biomarker for nutritional-immunological interplay in allergic inflammation and support targeted nutritional strategies in at-risk pediatric populations.