阿拉伯语莱斯特咳嗽问卷在慢性咳嗽患者中的跨文化调适与心理测量学验证：一项横断面研究

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中文摘要

背景： 慢性咳嗽显著影响患者的生活质量，但目前缺乏经过验证的阿拉伯语评估工具。本研究旨在翻译、跨文化调适并验证阿拉伯语版莱斯特咳嗽问卷（LCQ-A）在阿拉伯语患者中的适用性。方法：这项横断面研究涉及LCQ在阿拉伯语慢性咳嗽患者中的翻译、跨文化调适和心理测量学验证。参与者完成了LCQ-A和COPD评估测试（CAT）。采用Cronbach's α评估内部一致性，采用组内相关系数评估重测信度，并通过与CAT咳嗽条目的Spearman相关性评估收敛效度。结果：共招募56名成年慢性咳嗽患者，平均年龄为28.5±4.8岁。与慢性咳嗽相关的临床原因或状况包括感染后咳嗽（26.8%）、鼻窦炎（17.9%）、哮喘（14.3%）和不明原因（41.1%）。LCQ-A总分的平均值为16.9±3.7，各子领域得分为5.3±1.3（生理）、5.9±1.2（心理）和5.8±1.5（社会）。Cronbach's α显示各领域内部一致性极好（生理，0.870；心理，0.882；社会，0.925；总分，0.952）。在咳嗽症状无变化的参与者中，LCQ-A的重测信度极好，单项测量的组内相关系数值范围为0.859至0.944，平均测量为0.924至0.971（所有P<0.001）。观察到强的领域间相关性（ρ=0.877-0.957，P<0.001），表明内部一致性高。然而，LCQ-A评分与CAT咳嗽条目无显著相关性（ρ=-0.030至0.057，P>0.05）。结论：LCQ-A表现出极好的信度和强的内部一致性，证实其适用于评估阿拉伯语人群的咳嗽相关生活质量。虽然未观察到与CAT咳嗽条目的收敛效度，但LCQ-A为临床和研究使用提供了一种文化调适且心理测量学稳健的工具。

英文摘要

Chronic cough significantly impacts patients' quality of life, yet validated Arabic-language tools for its assessment are lacking. This study aimed to translate, culturally adapt, and validate the Arabic version of the Leicester Cough Questionnaire (LCQ-A) among Arabic-speaking patients. This cross-sectional study involved the translation, cross-cultural adaptation, and psychometric validation of the LCQ among Arabic-speaking patients with chronic cough. Participants completed the LCQ-A and the COPD Assessment Test (CAT). Internal consistency was assessed using Cronbach's α, test-retest reliability using intraclass correlation coefficients, and convergent validity via Spearman's correlation with the CAT cough item. A total of 56 adult patients with chronic cough were recruited with a mean age of 28.5 ± 4.8 years. Clinical causes or conditions associated with chronic cough included postinfection cough (26.8%), sinusitis (17.9%), asthma (14.3%), and an unknown cause (41.1%). The mean LCQ-A total score was 16.9 ± 3.7, with subdomain scores of 5.3 ± 1.3 (physical), 5.9 ± 1.2 (psychological), and 5.8 ± 1.5 (social). Cronbach's α demonstrated excellent internal consistency across domains (physical, 0.870; psychological, 0.882; social, 0.925; total, 0.952). Test-retest reliability of the LCQ-A in participants with no change in cough symptoms was excellent, with intraclass correlation coefficient values ranging from 0.859 to 0.944 for single measures and 0.924 to 0.971 for average measures (all P < .001). Strong interdomain correlations were observed (ρ = 0.877-0.957, P < .001), indicating high internal coherence. However, LCQ-A scores did not significantly correlate with the CAT cough item (ρ = -0.030 to 0.057, P > .05). The LCQ-A demonstrates excellent reliability and strong internal consistency, confirming its suitability for assessing cough-related quality of life in Arabic-speaking populations. While convergent validity with the CAT cough item was not observed, the LCQ-A provides a culturally adapted and psychometrically robust instrument for clinical and research use.