Article record

非嗜酸性粒细胞性食管炎嗜酸性胃肠道疾病与嗜酸性粒细胞性食管炎的临床特征、诊断挑战及治疗结局比较。

Clinical Characteristics, Diagnostic Challenges, and Therapeutic Outcomes in Non-eosinophilic Esophagitis Eosinophilic Gastrointestinal Diseases in Comparison with Eosinophilic Esophagitis.

临床研究咽喉科IF 1.4Q3

文献信息

PMID	42825915
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Azizollah Yousefi 查看其他 11 位作者 Saeed Sepehry Vafa；Mina Mirzad；Fatemeh Elham Mahjoub；Behnam Shahsavand；Ebrahim Babaee；Fereshteh Karbasian；Mohammad Nabavi；Mohammad Hasan Bemanian；Sima Shokri；Saba Arshi；Morteza Fallahpour
作者单位	Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran. Dra_yusefi@yahoo.com. 查看其他 11 条单位信息 Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. saeedexisepehry98@gmail.com.；Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. minawmirzadeh@gmail.com.；Department of Pathology, School of Medicine, Maternal, Fetal, and Neonatal Research Center, Family Health Research Institute, Iran University of Medical Sciences, Tehran, Iran. fmahjoub@sina.tums.ac.ir.；Department of Pediatrics, Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. behnamshahsavand@gmail.com.；Department of Community and Family Medicine, Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. dr.babaeeebrahim@gmail.com.；Department of Pediatric Gastroenterology and Hepatology, Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. karbasian.md@gmail.com.；Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. mnabavi44@yahoo.com.；Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. mhbemanian@yahoo.com.；Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. shokri.83@gmail.com.；Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. sabaarshi@yahoo.com.；Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. fallahpour.morteza@gmail.com.
期刊	Iranian journal of allergy, asthma, and immunology
SCI 分区	Q3
IF	1.4
研究类型	临床研究 · 临床
所属专科	咽喉科

中文摘要

嗜酸性粒细胞性胃肠道疾病（EGIDs）是慢性、TH2介导的疾病。嗜酸性粒细胞性食管炎（EoE）是最常见的类型，而非EoE EGIDs影响其他肠道节段。这项回顾性研究纳入2011年至2022年的111例患者（50例EoE和61例非EoE），比较了这两种类型的临床方面。吞咽困难和食物嵌塞在EoE中占主导，而腹痛、恶心和腹泻在非EoE EGIDs中更常见。特应性合并症常见。诊断延迟>1年在EoE中更常见（72% vs 47.5%）。总体临床缓解率为88.29%，大多数患者采用食物回避（90.99%）和质子泵抑制剂（94.59%）。在平均4.62年的随访中，38.88%发生临床复发，且不受治疗类型影响。生长迟缓见于26.7%，组间无显著差异。本研究强调EoE与非EoE EGIDs相比诊断延迟更长。两组显示出相似的良好缓解率，强调需要提高认识。需要采用标准化措施的前瞻性研究来优化管理。

英文摘要

Eosinophilic gastrointestinal diseases (EGIDs) are chronic, TH2-mediated conditions. Eosinophilic esophagitis (EoE) is the most common type, while non-EoE EGIDs affect other gut segments. This retrospective study of 111 patients (50 EoE and 61 non-EoE) from 2011 to 2022 compared the clinical aspects of these 2 types. Dysphagia and food impaction dominated in EoE, while abdominal pain, nausea, and diarrhea were more common in non-EoE EGIDs. Atopic comorbidities were frequent. Diagnostic delays>1 year were more common in EoE (72% vs 47.5%). The overall clinical response rate was 88.29%, with most patients using food avoidance (90.99%) and proton pump inhibitors (94.59%). Clinical relapses occurred in 38.88% over the mean follow-up of 4.62 years and were unaffected by therapy type. Failure to thrive was seen in 26.7%, with no significant intergroup difference. This study highlights a prolonged diagnostic delay in EoE vs non-EoE EGIDs. Both groups showed similar, favorable response rates, underscoring a need for greater awareness. Prospective studies with standardized measures are required to optimize management.