Article record

过敏性鼻炎中的嗜酸性粒细胞与淋巴细胞比值及血小板与淋巴细胞比值

Eosinophil-to-lymphocyte Ratio and Platelet-to-lymphocyte Ratio in Allergic Rhinitis.

综述 Meta鼻科IF 1.4Q3

文献信息

PMID	42825913
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Alireza Sharifi 查看其他 13 位作者 Maryam Sharifi；Elham Farasat；Maryam Yaghoubi Hamgini；Shohreh Norouzi；Selda Zahedi Abdi；Parsa Taghavi；Nadereh Alani；Shahram Seyedi；Mehran Jamali；Mohammad E Ghaffari；Samad Samadizadeh；Brent A Senior；Joseph Z Lebowitz
作者单位	1 Department of Otolaryngology-Head and Neck Surgery, Otorhinolaryngology Research Center, Amir A'lam Hospital, Tehran University of Medical Sciences, Tehran, Iran. sharifi.ali.rz@gmail.com. 查看其他 13 条单位信息 Student Research Committee, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. solaleh.sh@gmail.com.；Pediatric Clinical Research Development Unit, Hazrat Masoumeh Hospital, Qom University of Medical Sciences, Qom, Iran. farasat_med@yahoo.com.；ENT and Head and Neck Research Center and Department, The Five Senses Health Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. maryamyaghoobi1985@gmail.com.；Department of Otolaryngology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. sharifi.ali.rz@iran.ir.；Department of Anesthesiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. zahediabdi.s@iums.ac.ir.；Student Research Committee, School of Dentistry, Islamic Azad University, Tehran, Iran. Parsycho@gmail.com.；Department of Otolaryngology, School of Medicine, Qom University of Medical Sciences, Qom, Iran. sharifi.ali.rz@iran.ir.；Department of Microbiology and Immunology, School of Medicine, Islamic Azad University, Tehran, Iran. seyedish@gmail.com.；Department of Oral and Maxillofacial Surgery, School of Dentistry, Qom University of Medical Sciences, Qom, Iran. mehranjamali88@yahoo.com.；Department of Epidemiology and Biostatistics, Faculty of Health, Qom University of Medical Sciences, Qom, Iran. m.gh19@yahoo.com.；Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. sharifi.ali.rz@irani.ir.；Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA. brent_senior@med.unc.edu.；Department of Otolaryngology-Head and Neck Surgery, University of North Carolina, Chapel Hill, North Carolina, USA. joseph_lebowitz@med.unc.edu.
期刊	Iranian journal of allergy, asthma, and immunology
SCI 分区	Q3
IF	1.4
研究类型	综述 Meta · 临床
所属专科	鼻科

中文摘要

背景： 越来越多的文献探讨血清嗜酸性粒细胞与淋巴细胞比值（ELR）和血小板与淋巴细胞比值（PLR）在过敏性鼻炎（AR）患者中的诊断作用，但结果不一，且缺乏对潜在混杂变量的控制以及用于临床应用的标准化截断值。我们旨在通过系统评价和荟萃分析来阐明其作用。方法：系统检索了Web of Science、PubMed、Embase、Scopus、Cochrane对照试验中心注册库、Google Scholar和Medline，检索截止至2025年10月。检索策略由相关医学副主题词（MeSH）和关键词组合描述。对符合条件的英文研究进行了审查，并评估了其质量。本综述遵循系统评价和荟萃分析优先报告条目（PRISMA）指南。结果：共有12项研究、包括3 449名个体符合纳入标准。AR组的ELR显著高于对照组（SMD：0.64），PLR不显著低于对照组（SMD：-0.02）。持续性AR患者的ELR（SMD：1.19）和PLR（SMD：0.58）在数值上高于间歇性AR患者，但差异不显著。ELR值大于0.085在区分AR患者与对照组时的合并AUC为67%。该AUC率具有统计学显著性。结论：本综述发现平均PLR与AR之间未发现明确相关性。然而，在诊断为AR的患者中发现平均ELR显著升高，并观察到ELR随疾病严重程度增加而升高的数值趋势。尽管仍需进一步研究以确定其临床实用性。

英文摘要

A growing number of literatures explores the diagnostic role of serum eosinophil-to-lymphocyte ratio (ELR) and platelet-to-lymphocyte ratio (PLR) in patients with allergic rhinitis (AR), yielding variable findings and lacking control of potential confounding variables and standardized cut-offs for clinical application. We aim to clarify their role through a systematic review and meta-analysis. Web of Science, PubMed, Embase, Scopus, Cochrane Central Register of Control Trials, Google Scholar, and Medline were systematically searched up to October, 2025. The search strategy was described by a combination of relevant medical subheadings (MeSH) and keywords. Eligible English language studies were reviewed, and their quality was appraised. This review adhered to Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. A total of 12 studies, including 3 449 individuals, met the inclusion criteria. AR group had significantly higher ELR (SMD: 0.64) and insignificantly lower PLR (SMD-0.02) than control. Patients with persistent AR had, numerically but not significantly, higher ELR (SMD: 1.19) and PLR (SMD: 0.58) compared to intermittent AR. ELR value of greater than 0.085 had a pooled AUC of 67% in discrimination of patients with AR from control. This AUC rate was statistically significant. This review investigated that no clear correlation was found between mean PLR and AR. However, mean ELR was found to be significantly increased in patients with a diagnosis of AR, and a numerical trend toward higher ELR with greater disease severity was observed. Though further research is necessary to determine its clinical utility.