正常妊娠与嗓音：一项关于喉部与嗓音结局的PRISMA-ScR范围综述
Normal Pregnancy and Voice: A PRISMA-ScR Scoping Review of Laryngeal and Vocal Outcomes.
文献信息
| PMID | 42825795 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | John M Boyd |
| 作者单位 | Department of Otolaryngology-Head and Neck Surgery, NYU Langone Health, New York, New York, USA. |
| 期刊 | The Laryngoscope |
| SCI 分区 | Q2 |
| IF | 2.3 |
| 研究类型 | 综述 Meta · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 妊娠会产生可能影响喉部组织、发声呼吸支持及嗓音质量的生理适应。我们进行了一项范围综述，探讨妊娠对嗓音和喉部结局的影响。
数据来源： PubMed、CINAHL和Web of Science。
综述方法： 按照PRISMA-ScR指南进行范围综述。对PubMed、CINAHL和Web of Science的检索共获得1350项研究，由两名评价者在Covidence中筛选。在审查的107篇全文中有22篇符合纳入标准。我们纳入了以妊娠为主要暴露并测量嗓音相关结局的人类研究。当妊娠特异性动物研究用于模拟喉部改变机制时也被纳入。
结果： 22项研究符合纳入标准，并被归入以下领域：声学/空气动力学（n=16）、患者报告/感知（n=12）、喉部生理学（n=5）、机制性动物研究（n=4）、歌唱嗓音（n=4）和呼吸（n=1）；若干研究贡献于多个领域。声学指标（基频、jitter、shimmer）通常无变化，而多项研究报告妊娠期间最大发声时间（MPT）缩短。主观嗓音指标倾向于恶化，歌唱者研究报告音域缩小和音色改变。生理学研究注意到声带水肿增加和活动度降低，在妊娠晚期最为明显。机制模型支持激素相关的黏膜改变和喉部蛋白表达改变。
结论： 关于妊娠期间嗓音改变的文献有限且异质性大，证据集中在妊娠晚期。与显著的声学嗓音改变相比，妊娠更一致地与发声效率降低和感知嗓音功能变差相关。
证据等级： 不适用。
英文摘要
OBJECTIVE: Pregnancy produces physiologic adaptations that may affect laryngeal tissues, respiratory support for phonation, and voice quality. We performed a scoping review exploring the influence of pregnancy on voice and laryngeal outcomes.
DATA SOURCES: PubMed, CINAHL, and Web of Science.
REVIEW METHODS: A scoping review was conducted per PRISMA-ScR guidelines. Searches of PubMed, CINAHL, and Web of Science yielded 1350 studies screened in Covidence by two reviewers. Of 107 full texts reviewed, 22 met inclusion criteria. We included human studies in which pregnancy was the primary exposure and voice-related outcomes were measured. Pregnancy-specific animal studies were included when modeling mechanisms of laryngeal change.
RESULTS: Twenty-two studies met inclusion criteria and were grouped into domains: acoustic/aerodynamic (n = 16), patient-reported/perceptual (n = 12), physiologic laryngeal (n = 5), mechanistic animal studies (n = 4), singing voice (n = 4), and respiratory (n = 1); several studies contributed to multiple domains. Acoustic measures (fundamental frequency, jitter, shimmer) were generally unchanged, while multiple studies reported reduced maximum phonation time (MPT) during pregnancy. Subjective voice measures tended to worsen, and singer studies reported reduced vocal range and timbre changes. Physiologic studies noted increased vocal fold edema and reduced motility, most prominent in the third trimester. Mechanistic models supported hormone-associated mucosal changes and altered laryngeal protein expression.
CONCLUSIONS: The literature on voice changes during pregnancy is limited and heterogeneous, with evidence concentrated in late pregnancy. Pregnancy is more consistently associated with reduced phonatory efficiency and worse perceived voice function than with major acoustic vocal changes.
LEVEL OF EVIDENCE: N/A.