积极心理特质、感知配偶支持与头颈癌特异性健康相关生活质量之间的关系：一项在肿瘤治疗环境中的横断面研究。
Relationship between positive psychological traits, perceived spousal support and head and neck cancer-specific health-related quality of life: a cross-sectional study in oncology treatment settings.
文献信息
| PMID | 42823118 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Yamunaa Sai Mohana Rao |
| 作者单位 | Universiti Sultan Zainal Abidin Fakulti Perubatan, Kuala Terengganu, Terengganu, Malaysia. |
| 期刊 | BMJ open |
| SCI 分区 | Q2 |
| IF | 2.8 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻咽癌 |
中文摘要
目的： 在肿瘤治疗环境中，使用马来语验证工具探讨积极心理特质和感知配偶支持与头颈癌（HNC）特异性健康相关生活质量（QOL）关系的数据很少。因此，本研究：（1）评估人口学和临床特征、乐观、创伤后成长（PTG）、希望、感知配偶支持与HNC特异性健康相关QOL之间的关联；（2）在HNC患者队列中评估PTG、感知配偶支持和希望对乐观与HNC特异性健康相关QOL之间关系的中介作用。
设计： 横断面研究。
地点： 本研究在马来西亚两个肿瘤治疗三级转诊中心进行。
参与者： 从总共240名HNC患者中收集数据。
主要和次要结局指标： 主要结局是使用35项欧洲癌症研究与治疗组织生活质量-头颈模块评估的HNC特异性健康相关QOL，次要结局是使用生活取向测试-修订版测量的乐观、使用创伤后成长量表-简表测量的PTG、使用社会支持来源量表评估的感知配偶支持以及使用特质希望量表评估的希望。
结果： 较高的感知配偶支持（B=-0.454，95% CI -0.781至-0.126，p=0.007）和乐观（B=-2.001，95% CI -2.660至-1.342，p<0.001）与更好的HNC特异性健康相关QOL显著相关，但与PTG（p=0.772）和希望（p=0.081）无关。此外，鼻咽癌患者和仅接受化疗的患者分别比其他HNC肿瘤患者（B=-8.586，95% CI 2.927至14.245，p=0.003）和接受手术、化疗和放疗联合治疗的患者（B=-10.864，95% CI -18.897至-2.831，p=0.008）具有显著更好的HNC特异性健康相关QOL。同时，较高的感知配偶支持部分中介了乐观与改善的HNC特异性健康相关QOL之间的关联，但未中介PTG和希望。
结论： 乐观和感知配偶支持可能与HNC特异性健康相关QOL呈正相关。
英文摘要
OBJECTIVES: Data on how positive psychological traits and perceived spousal support are related to head and neck cancer (HNC)-specific health-related quality of life (QOL) using validated instruments in the Malay language in oncology settings are scarce. Hence, this study: (1) evaluated the association between demographic and clinical characteristics, optimism, posttraumatic growth (PTG), hope, perceived spousal support and HNC specific health-related QOL; and (2) assessed the mediation associations of PTG, perceived spousal support and hope on the relationship between optimism and HNC specific health-related QOL among a cohort of patients with HNC.
DESIGN: Cross-sectional study.
SETTINGS: This study was conducted in two tertiary referral centres for oncology treatment in Malaysia.
PARTICIPANTS: Data were collected from a total of 240 patients with HNC.
PRIMARY AND SECONDARY OUTCOME MEASURES: The primary outcome was HNC specific health-related QOL assessed with the 35-item European Organisation for Research and Treatment of Cancer Quality of Life-Head and Neck Module, while the secondary outcomes were optimism measured with the Life Orientation Test-Revised, PTG measured with the Posttraumatic Growth Inventory-Short Form, perceived spousal support evaluated with the Sources of Social Support Scale and hope assessed with the Dispositional Hope Scale.
RESULTS: Higher perceived spousal support (B=-0.454, 95% CI -0.781 to -0.126, p=0.007) and optimism (B=-2.001, 95% CI -2.660 to -1.342, p<0.001) were significantly associated with greater HNC specific health-related QOL but not PTG (p=0.772) and hope (p=0.081). In addition, those with nasopharyngeal carcinoma and those on chemotherapy alone had significantly greater HNC specific health-related QOL than those with other HNC tumours (B=-8.586, 95% CI 2.927 to 14.245, p=0.003) and those who combined surgery, chemotherapy and radiotherapy, respectively (B=-10.864, 95% CI -18.897 to -2.831, p=0.008). Meanwhile, greater perceived spousal support partially mediated the association of optimism and improved HNC-specific health-related QOL but not PTG and hope.
CONCLUSION: Optimism and perceived spousal support may have a positive association with HNC-specific health-related QOL.