Article record

优化高压氧治疗突发性听力损失。

Optimizing Hyperbaric Oxygen Therapy for Sudden Hearing Loss.

临床研究耳科IF 2.9Q1

文献信息

PMID	42820475
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Yuting Sun 查看其他 5 位作者 Yu Yang；Zhentao Wang；Hui Zhao；Xiaoli Ge；Shuming Pan
作者单位	Emergency Department, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. 查看其他 4 条单位信息 Emergency Department, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.；Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.；Department of Otolaryngology Head Neck Surgery, Eye & Ear Nose Throat Hospital, Fudan University, 83 Fenyang Rd, Shanghai, China.；Emergency Department, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
期刊	Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
SCI 分区	Q1
IF	2.9
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

目的： 通过一项多中心回顾性队列研究，确定最有效的疗程并分析关键预后因素，以优化突发性感音神经性听力损失的高压氧治疗方案。
研究设计： 回顾性队列研究。
地点： 本研究在中国上海4家配备高压氧（HBO）设施的三级医院进行。患者入组时间为2022年1月至2024年9月。参与者从参与中心就诊的突发性感音神经性听力损失（SSNHL）患者的临床记录中识别。
方法： 这项多中心回顾性队列研究（n=1309）纳入了符合2019年AAO-HNS指南的患者。HBO组（n=991）接受2.2 ATA HBO联合皮质类固醇治疗，而非HBO组（n=318）仅接受皮质类固醇治疗。主要和次要结局分别为治疗完成时和90天随访时的听力恢复率。
结果： 11至20次HBO治疗显著提高了治疗完成时的轻微恢复率（OR=2.205，95% CI：1.399-3.474，P=.001）和部分恢复率（OR=2.236，95% CI：1.429-3.500，P<.001），但未提高完全恢复率。在90天时，11至20次治疗显著促进了完全恢复（OR=0.422，95% CI：0.224-0.793，P=.007）。疗效受初始听力损失程度的显著影响；全聋患者的部分恢复率低于较轻听力损失患者，而极重度耳聋患者的部分恢复率最高（125.3%）。年龄、延迟治疗、眩晕和高初始纯音阈值是独立预后因素（P<.05）。未发生严重不良事件。
结论： HBO联合皮质类固醇可改善SSNHL的听力恢复。建议尽早开始10至20次HBO治疗，最好在发病后两周内，尤其是对于重度和全聋患者。未来研究应标准化疗效标准，以推进个体化治疗。

英文摘要

OBJECTIVE: To optimize the hyperbaric oxygen therapy protocol for sudden sensorineural hearing loss by identifying the most effective treatment course and analyzing key prognostic factors through a multicenter retrospective cohort study.
STUDY DESIGN: Retrospective cohort study.
SETTING: The study conducted at 4 tertiary hospitals equipped with hyperbaric oxygen (HBO) facilities in Shanghai, China. Patient enrollment occurred between January 2022 and September 2024. Participants were identified from the clinical records of patients presenting with sudden sensorineural hearing loss (SSNHL) at the participating centers.
METHODS: This multicenter retrospective cohort study (n = 1309) enrolled patients meeting 2019 AAO-HNS guidelines. The HBO group (n = 991) received 2.2 ATA HBO combined with corticosteroids, while the non-HBO group (n = 318) received corticosteroids alone. Primary and secondary outcomes were hearing recovery rates at treatment completion and 90-day follow-up, respectively.
RESULTS: 11 to 20 HBO sessions significantly increased rates of slight (OR = 2.205, 95% CI: 1.399-3.474, P = .001) and partial recovery (OR = 2.236, 95% CI: 1.429-3.500, P < .001) at treatment completion, but not complete recovery. At 90 days, 11 to 20 sessions significantly promoted complete recovery (OR = 0.422, 95% CI: 0.224-0.793, P = .007). Efficacy was significantly influenced by initial hearing loss degree; patients with total deafness showed lower partial recovery rates versus those with milder losses, while patients with very severe deafness showed the highest (125.3%). Age, delayed treatment, vertigo, and high initial pure-tone threshold were independent prognostic factors (P < .05). No serious adverse events occurred.
CONCLUSION: HBO combined with corticosteroids improves hearing recovery in SSNHL. Initiating 10 to 20 HBO sessions early, preferably within two weeks of onset, is recommended, especially for severe and total deafness. Future studies should standardize efficacy criteria to advance individualized treatment.