Article record

乌干达CMV流行人群中先天性巨细胞病毒感染的患病率

Prevalence of Congenital Cytomegalovirus Infection in a CMV-Endemic Ugandan Population.

临床研究耳科IF 3.5Q2

文献信息

PMID	42819885
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Amy K F Davis 查看其他 10 位作者 Mary K Prahl；Mikias Ilala；Justine Levan；Pamela M Odorizzi；Mary Muhindo；Abel Kakuru；Stephanie L Gaw；Moses R Kamya；Grant Dorsey；Margaret E Feeney
作者单位	Department of Pediatrics, University of California, San Francisco, California, USA. 查看其他 4 条单位信息 Department of Medicine, University of California, San Francisco, California, USA.；Infectious Diseases Research Collaboration, Kampala, Uganda.；Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, California, USA.；Department of Medicine, Makerere University, Kampala, Uganda.
期刊	Open forum infectious diseases
SCI 分区	Q2
IF	3.5
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

先天性巨细胞病毒（cCMV）感染是全球儿童耳聋和残疾的主要原因。然而，在大多数女性受孕时CMV血清阳性的低收入地区，对其流行病学知之甚少。我们发现，cCMV在乌干达农村地区高度流行（3.73%），并与较低的孕次和胎盘疟疾相关。我们还报告了生命最初几年的高传播强度，97.3%的儿童在3岁时已获得CMV IgG。

英文摘要

Congenital cytomegalovirus (cCMV) infection is a leading cause of childhood deafness and disability worldwide. However, less is known about its epidemiology in low-income regions where most women are CMV-seropositive at conception. We found that cCMV is highly prevalent in rural Uganda (3.73%) and is associated with lower gravidity and placental malaria. We additionally report a high transmission intensity in the first years of life, with 97.3% of children acquiring CMV IgG by age 3.