Article record

全反式维甲酸联合化疗后急性早幼粒细胞白血病在中耳的髓外复发

Extramedullary Relapse of Acute Promyelocytic Leukemia in the Middle Ear after All-Trans Retinoic Acid Combined with Chemotherapy.

临床研究耳科IF 1Q3

文献信息

PMID	42816398
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Noriko Tsuge 查看其他 10 位作者 Taisuke Kobayashi；Masahiro Komori；Ichiro Murakami；Tatsuya Negishi；Shohei Shigeto；Yuta Tsunaga；Keito Ohara；Shinichiro Watanabe；Shohei Yoshida；Kensuke Kojima
作者单位	Department of Hematology, Kochi Medical School, Kochi University, Japan. 查看其他 3 条单位信息 Department of Otolaryngology, Kochi Medical School, Kochi University, Japan.；Department of Pathology, Kochi Medical School, Kochi University, Japan.；Department of Laboratory Medicine, Shinshu University Hospital, Japan.
期刊	Internal medicine (Tokyo, Japan)
SCI 分区	Q3
IF	1
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

一名69岁男性急性早幼粒细胞白血病患者处于分子学缓解状态，外周血细胞中未检测到PML::RARA转录本，随后发生急性中耳炎。10个月后，因怀疑继发性胆脂瘤而施行鼓室乳突切除术。组织学检查证实为PML::RARA阳性细胞浸润的髓外复发。患者在接受三氧化二砷治疗后达到第二次分子学缓解。我们的发现提示：（1）诊断样本可从乳突气房而非中耳腔获取；（2）分子学缓解并不排除髓外复发；（3）全反式维甲酸与三氧化二砷联合治疗可能降低髓外复发的风险。

英文摘要

A 69-year-old man with acute promyelocytic leukemia in molecular remission and no detectable PML::RARA transcripts in his peripheral blood cells developed acute otitis media. After 10 months, tympanomastoidectomy was performed for suspected secondary cholesteatoma. A histological examination confirmed extramedullary relapse with PML::RARA-positive cell infiltration. The patient achieved a second molecular remission after treatment with arsenic trioxide. Our findings suggest that (1) a diagnostic sample may be obtained from mastoid air cells rather than from the middle ear cavity, (2) molecular remission does not preclude extramedullary relapse, and (3) all-trans retinoic acid and arsenic trioxide combination therapy may reduce the risk of extramedullary relapse.