扁桃体内类固醇注射缩小扁桃体肥大患者腭扁桃体体积的疗效：一项随机对照试验
Efficacy of Intratonsillar Steroid Injection for Reducing Palatine Tonsil Size in Tonsillar Hypertrophy: A Randomized Controlled Trial.
文献信息
| PMID | 42813210 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Arunrat Dumkliang |
| 作者单位 | Department of Otorhinolaryngology, Thungsong Hospital, Thungsong, Nakhon Si Thammarat, Thailand. |
| 期刊 | International archives of otorhinolaryngology |
| SCI 分区 | Q3 |
| IF | 1.4 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
引言： 扁桃体切除术是阻塞性睡眠呼吸暂停（OSA）的常见治疗方法，也是全球最常实施的外科手术之一。然而，术后并发症仍是持续存在的临床问题。扁桃体内类固醇注射可能通过缩小肥大的腭扁桃体体积，提供一种非手术替代方案。
目的： 本研究旨在评估扁桃体内类固醇注射与病灶内注射生理盐水（NSS）相比，在扁桃体肥大中的疗效和安全性。
研究设计： 前瞻性研究（随机对照试验）。
材料与方法： 在这项随机对照试验中，19名参与者（38个扁桃体）被分配到四组，接受扁桃体内注射曲安奈德（TA，40 mg/mL，1 mL）或生理盐水（1 mL）。九名参与者在第0、4和8周接受多次注射；十名接受单次注射。每次注射前测量扁桃体大小，以评估缩小腭扁桃体体积的临床疗效。
结果： 类固醇注射后扁桃体大小显著缩小，仅在多次类固醇注射组中观察到统计学显著差异（p值=0.04）。与生理盐水注射组相比，类固醇注射组的疼痛略多，但两组均未观察到严重不良事件。
结论： 与生理盐水注射相比，扁桃体内类固醇注射有效缩小了腭扁桃体体积。重复类固醇注射比单次注射更有效。
英文摘要
INTRODUCTION: Tonsillectomy is a common treatment for obstructive sleep apnea (OSA) and remains one of the most frequently performed surgical procedures worldwide. However, postoperative morbidity is a persistent clinical concern. Intratonsillar steroid injection may offer a non-surgical alternative by reducing the size of hypertrophic palatine tonsils.
OBJECTIVE: this study aims to evaluate the efficacy and safety of intratonsillar steroid injections compared to intralesional injections of normal saline solution (NSS) in tonsillar hypertrophy.
STUDY DESIGN: Prospective study (Randomized control trial).
MATERIALS AND METHODS: In this randomized controlled trial, 19 participants (38 tonsils) were assigned to four groups receiving intratonsillar injections of triamcinolone acetonide (TA, 40 mg/mL, 1 mL) or NSS (1 mL). Nine participants received multiple injections at weeks 0, 4, and 8; ten received a single injection. Tonsil size was measured before each injection to assess the clinical efficacy of reducing palatine tonsil size.
RESULTS: There was a significant reduction in tonsil size after steroid injections, with a statistically significant difference observed only in the multiple steroid injection group (p-value = 0.04). The steroid injection group experienced slightly more pain compared to the NSS injection group, however, no severe adverse effects were observed in either group.
CONCLUSION: Intratonsillar steroid injections effectively reduced the size of palatine tonsils compared with NSS injections. Repeated steroid injections were more effective than a single injection.