年龄对日本患者人群中阻塞性睡眠呼吸暂停与代谢综合征关联的影响。
Effects of age on association between obstructive sleep apnea and metabolic syndrome in the Japanese patient population.
文献信息
| PMID | 42812685 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Keisuke Kataoka |
| 作者单位 | Division of Molecular Oncology, National Cancer Center Research Institute, Tokyo, Japan. |
| 期刊 | Sleep and biological rhythms |
| SCI 分区 | Q3 |
| IF | 2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 咽喉科 |
中文摘要
目的： 既往研究提示阻塞性睡眠呼吸暂停（OSA）与代谢综合征（MetS）之间存在关联。衰老会影响OSA和MetS的患病率以及二者之间的关系。然而，在老年和非老年日本患者中是否可观察到OSA与MetS之间的关系仍不清楚。
方法： 分析了通过整夜多导睡眠监测诊断为OSA的患者数据。所有患者按年龄分为两组：<60岁或≥60岁。根据日本标准判定的MetS共存情况在不同OSA严重程度间进行比较。
结果： 在338例年龄<60岁的患者中，包括182例重度OSA，MetS患病率随OSA严重程度增加而升高（轻度13.3%、中度31.5%、重度46.7%；P<0.001）。在145例年龄≥60岁的患者中，包括68例重度OSA，MetS患病率也随OSA严重程度增加而升高（轻度16.0%、中度28.8%、重度45.6%；P=0.016）。年龄组与OSA严重程度/MetS关系之间无交互作用，提示OSA严重程度与MetS之间的关系在非老年组和老年组中相似。在年龄<60岁患者的校正分析中，与轻度OSA相比，重度OSA与更高的MetS风险相关（比值比[OR]，3.9；95%置信区间[CI，1.5-10.0]）；在年龄≥60岁患者中，重度OSA与MetS相关呈非显著趋势（OR，2.9；95%CI，0.8-10.1）。
结论： 在该人群中，MetS患病率随OSA严重程度增加而升高，且这种关联在老年和非老年日本患者中相似。
英文摘要
PURPOSE: Previous studies have suggested a relationship between obstructive sleep apnea (OSA) and metabolic syndrome (MetS). Aging affects the prevalence of OSA and MetS and the relationship between them. However, whether a relationship between OSA and MetS can be observed in elderly and non-elderly Japanese patients remains unclear.
METHODS: Data from patients diagnosed with OSA using overnight polysomnography were analyzed. All patients were divided into two groups by age: <60 or ≥ 60 years. The coexistence of MetS, determined according to the Japanese criteria, was compared across the severity of OSA.
RESULTS: In 338 patients aged < 60 years including 182 with severe OSA, MetS prevalence increased with OSA severity (13.3% in mild, 31.5% in moderate, and 46.7% in severe; P < 0.001). In 145 patients aged ≥ 60 years including 68 with severe OSA, MetS prevalence also increased with OSA severity (16.0% in mild, 28.8% in moderate, and 45.6% in severe; P = 0.016). There was no interaction between age group and the OSA severity/MetS relationship, suggesting that the relationship between OSA severity and MetS was similar in the non-elderly and elderly groups. In the adjusted analysis of patients aged < 60 years, severe OSA was associated with a higher risk of MetS compared to mild OSA (odds ratio [OR], 3.9; 95% confidence interval [CI, 1.5-10.0]); in those aged ≥ 60 years, severe OSA had a non-significant tendency to be associated with MetS (OR, 2.9; 95%CI, 0.8-10.1).
CONCLUSIONS: MetS prevalence increased with OSA severity in this population, and the associations were similar in elderly and non-elderly Japanese patients.