Article record

突发性感音神经性听力损失与病毒关联：疱疹病毒和SARS-CoV-2的血清学证据。

Sudden sensorineural hearing loss and viral association: serological evidence of herpesviruses and SARS-CoV-2.

临床研究耳科IF 2.1Q2

文献信息

PMID	42809912
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Tracy Lima Tavares Soeiro 查看其他 6 位作者 Marina Cançado Passarelli Scott；Breno Lima de Almeida；Jônatas Bussador do Amaral；Elizabeth Cristina Perez；Sujana S Chandrasekhar；Norma de Oliveira Penido
作者单位	Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Department of Otorhinolaryngology-Head and Neck Surgery, São Paulo, SP, Brazil. 查看其他 5 条单位信息 Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Department of Otorhinolaryngology-Head and Neck Surgery, São Paulo, SP, Brazil. Electronic address: breno.almeida@unifesp.br.；Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Department of Otorhinolaryngology-Head and Neck Surgery, São Paulo, SP, Brazil; ENT Research Lab, Department of Otorhinolaryngology Head and Neck Surgery, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil. Electronic address: jbamaral@unifesp.br.；Graduate Program in Environmental and Experimental Pathology, Paulista University, São Paulo, Brazil.；ENT and Allergy Associates, LLP, New York, United States of America. Electronic address: ssc@nyotology.com.；Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM), Department of Otorhinolaryngology-Head and Neck Surgery, São Paulo, SP, Brazil. Electronic address: n.penido@unifesp.br.
期刊	Brazilian journal of otorhinolaryngology
SCI 分区	Q2
IF	2.1
研究类型	临床研究 · 临床
所属专科	耳科

中文摘要

目的： 探讨突发性感音神经性听力损失（SSNHL）急性期疱疹病毒（HSV-1、HSV-2、VZV、EBV、CMV）与SARS-CoV-2之间的关联，并将血清学和PCR结果与临床及听力学结局进行相关性分析。
方法： 前瞻性队列研究，纳入2020年3月至2024年2月期间评估的53例患者。进行了听力学评估、血清学检测（IgM和IgG）、疱疹病毒和SARS-CoV-2的PCR检测以及磁共振成像。
结果： 大多数患者（90.6%）表现为单侧听力损失。43.4%的病例观察到病毒暴露的血清学证据，包括SARS-CoV-2（26.4%）、HSV（22.6%）和CMV（5.6%）。11.3%的患者发生两种病毒共感染，并与较差的听力结局相关（p = 0.0032）。双侧听力损失（9.4%）也与无改善相关（p = 0.0368）。在多变量分析中，COVID-19感染仍与较差的结局独立相关。
结论： SSNHL与高频率的病毒血清学标志物相关。病毒共感染可能与较差的预后相关，尽管无法确定因果关系。初始听力损失严重程度和双侧受累仍是重要的预后因素。血清学发现可作为临床特征描述和预后评估的补充工具，尽管其病因学作用仍不确定。

英文摘要

OBJECTIVE: To investigate the association between Herpesviruses (HSV-1, HSV-2, VZV, EBV, CMV) and SARS-CoV-2 in the acute phase of Sudden Sensorineural Hearing Loss (SSNHL), correlating serological and PCR findings with clinical and audiometric outcomes.
METHODS: Prospective cohort study including 53 patients evaluated between March 2020 and February 2024. Audiological assessment, serological testing (IgM and IgG), PCR for herpesviruses and SARS-CoV-2, and magnetic resonance imaging were performed.
RESULTS: Most patients (90.6%) presented with unilateral hearing loss. Serological evidence of viral exposure was observed in 43.4% of cases, including SARS-CoV-2 (26.4%), HSV (22.6%), and CMV (5.6%). Coinfection with two viruses occurred in 11.3% of patients and was associated with poorer hearing outcomes (p = 0.0032). Bilateral hearing loss (9.4%) was also associated with no improvement (p = 0.0368). In multivariate analysis, COVID-19 infection remained independently associated with poorer outcomes.
CONCLUSION: SSNHL was associated with a high frequency of viral serological markers. Viral coinfection may be associated with poorer prognosis, although causality cannot be established. Initial hearing loss severity and bilateral involvement remained important prognostic factors. Serological findings may serve as complementary tools for clinical characterization and prognostic assessment, although their etiological role remains uncertain.