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氧化应激：慢性鼻窦炎炎症与内型的关键调节因子

Oxidative stress: a pivotal regulator of inflammation and endotypes in Chronic rhinosinusitis.

综述 Meta鼻科IF 4.1Q2

文献信息

PMID42808957
原文在 PubMed 查看原文 ↗
发表日期2026
作者Xinlei Niu
查看其他 8 位作者

Xiaozhe Yang；Haiyan Xu；Fei Gao；Xiaoyu Pu；Zhongyi Wang；Chao Cai；Xiangdong Wang；Luo Zhang

作者单位Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
查看其他 6 条单位信息

Key Laboratory of Otolaryngology Head and Neck Surgery, Ministry of Education, Beijing Laboratory of Allergic Diseases, Beijing Municipal Education Commission.；Beijing Key Laboratory of Nasal Diseases, Beijing Institute of Otolaryngology, Beijing, China.；Research Unit of Diagnosis and Treatment of Chronic Nasal Diseases, Chinese Academy of Medical Sciences, Beijing, China.；Department of Otolaryngology Head and Neck Surgery, Beijing You'an Hospital, Capital Medical University, Beijing, China.；Department of Otorhinolaryngology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.；Department of Allergy, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

期刊Expert review of clinical immunology
SCI 分区Q2
IF4.1
研究类型综述 Meta · 临床
所属专科鼻科

中文摘要

引言： 慢性鼻窦炎（CRS）是一种异质性炎症性疾病，具有不同的免疫内型和可变的临床结局。氧化应激通过连接上皮损伤、持续性炎症和组织重塑，促进了这种异质性。
涵盖领域： 检索了PubMed中2016年1月至2025年12月发表的相关研究。在适当情况下纳入了更早的重要研究。过量的活性氧（ROS）和受损的抗氧化防御破坏了黏膜氧化还原平衡并维持炎症。嗜酸性粒细胞和中性粒细胞通过不同但重叠的氧化机制发挥作用。它们的共存可能在混合内型中加剧炎症。氧化还原改变可能有助于内型分类、预后和治疗评估。抗氧化剂和其他氧化还原靶向方法在实验模型中显示出前景。
专家意见： 针对氧化还原治疗的临床证据仍然有限。定义内型特异性的氧化还原谱可能改善疾病分层，并阐明恢复氧化还原平衡是否能改善临床结局。

英文摘要

INTRODUCTION: Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease with distinct immune endotypes and variable clinical outcomes. Oxidative stress contributes to this heterogeneity by linking epithelial injury, persistent inflammation, and tissue remodeling.
AREAS COVERED: PubMed was searched for relevant studies published between January 2016 and December 2025. Earlier seminal studies were included when appropriate. Excess reactive oxygen species (ROS) and impaired antioxidant defenses disrupt mucosal redox balance and sustain inflammation. Eosinophils and neutrophils contribute through distinct but overlapping oxidative mechanisms. Their coexistence may intensify inflammation in mixed endotypes. Redox alterations may aid endotype classification, prognosis, and treatment assessment. Antioxidants and other redox-targeted approaches have shown promise in experimental models.
EXPERT OPINION: Clinical evidence for redox-targeted treatment remains limited. Defining endotype-specific redox profiles may improve disease stratification and clarify whether restoring redox balance improves clinical outcomes.