比较伴有和不伴有嗜睡症的阻塞性睡眠呼吸暂停患者的人口学和临床特征：一项横断面研究。
Comparing Demographic and Clinical Features of Obstructive Sleep Apnea Patients With and Without Sleepiness: A Cross-Sectional Study.
文献信息
| PMID | 42808328 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Fatemeh Kashaninasab |
| 作者单位 | Sleep Medicine Fellowship. Department of Psychiatry, Rasool Akram Medical Complex Clinical Research Development Center (RCRDC), Iran University of Medical Sciences (IUMS), Tehran, Iran. |
| 期刊 | Brain and behavior |
| SCI 分区 | Q2 |
| IF | 3.2 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
背景： 日间过度嗜睡（EDS）是阻塞性睡眠呼吸暂停（OSA）中常见但多变的症状，其与疾病严重程度和临床特征的关联尚不明确。本研究旨在比较伊朗人群中伴有和不伴有EDS的OSA患者的人口学和临床特征。
方法： 在这项横断面研究中，于2022年4月至2023年3月在伊朗德黑兰Rasoul Akram医院招募了117名年龄在18-65岁、经多导睡眠图确诊为OSA的患者。使用Epworth嗜睡量表（ESS ≥ 10）评估EDS。收集了人口学、人体测量学、临床变量（如AHI）和病史数据。统计分析包括Spearman相关、t检验、Mann-Whitney U检验和卡方检验。
结果： 在117名患者中（63.2%为男性，平均年龄38.18 ± 2.43岁），42.7%患有EDS。未发现AHI与ESS之间存在显著相关性（ρ = 0.121，p = 0.194），嗜睡组与非嗜睡组之间OSA严重程度（轻度、中度、重度）也无差异（p = 0.998）。AHI与年龄、体重、BMI、颈围和腰围相关（p < 0.05）；ESS与身高、体重和颈围相关（p < 0.05）。头/颈部疾病或损伤与EDS的缺失相关（p = 0.014），阿片类药物使用与EDS存在关联趋势（p = 0.082）。
结论： OSA患者的EDS与AHI并无强烈关联，但与特定的人体测量学特征相关。新发现的头/颈部疾病关联提示神经系统对EDS的影响。这些结果支持在中东人群中进行表型特异性的OSA管理。
英文摘要
BACKGROUND: Excessive daytime sleepiness (EDS) is a common but variable symptom in obstructive sleep apnea (OSA), with unclear associations with disease severity and clinical features. This study aimed to compare demographic and clinical characteristics of OSA patients with and without EDS in an Iranian population.
METHODS: In this cross-sectional study, 117 patients aged 18-65 years with polysomnography-confirmed OSA were recruited at Rasoul Akram Hospital, Tehran, Iran, from April 2022 to March 2023. EDS was assessed using the Epworth Sleepiness Scale (ESS ≥ 10). Data on demographics, anthropometric measures, clinical variables (e.g., AHI), and medical history were collected. Statistical analyses included Spearman correlations, t-tests, Mann-Whitney U tests, and chi-square tests.
RESULTS: Of 117 patients (63.2% male, mean age 38.18 ± 2.43 years), 42.7% had EDS. No significant correlation was found between AHI and ESS (ρ = 0.121, p = 0.194), nor differences in OSA severity (mild, moderate, severe) between sleepy and non-sleepy groups (p = 0.998). AHI correlated with age, weight, BMI, neck, and waist circumference (p < 0.05); ESS correlated with height, weight, and neck circumference (p < 0.05). Head/neck disease or injury was associated with the absence of EDS (p = 0.014), with a trend linking opioid use to EDS (p = 0.082).
CONCLUSIONS: EDS in OSA patients is not strongly tied to AHI but is associated with specific anthropometric features. The novel head/neck disease finding suggests neurological influences on EDS. These results advocate for phenotype-specific OSA management in Middle Eastern populations.