先天性巨细胞病毒感染作为年轻人群梅尼埃病病因：病例系列研究
Congenital Cytomegalovirus Infection as a Cause of Meniere's Disease in a Young Population: A Case Series.
文献信息
| PMID | 42806528 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Karolina Falkenius-Schmidt |
| 作者单位 | Department of Otorhinolaryngology, Head and Neck Surgery, Skåne University Hospital, Lund, Sweden. |
| 期刊 | Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale |
| SCI 分区 | Q1 |
| IF | 2.7 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
重要性： 先天性巨细胞病毒（cCMV）是产前感染最常见的原因，也是儿童期感音神经性听力损失最主要的感染性病因。新数据表明，前庭功能障碍在cCMV感染儿童中很常见。人类内淋巴积水与cCMV感染之间的关联仍存争议，研究报告仍然稀少。
目的： 突出年轻个体中梅尼埃病的潜在亚组，并支持既往关于cCMV感染儿童复发性前庭功能障碍的发现。
设计： 对临床病例系列进行的回顾性描述性研究。
地点： 瑞典Skåne大学医院、Karolinska大学医院和Sahlgrenska大学医院。
参与者： 确诊cCMV感染且出现梅尼埃病症状、发病年龄在25岁之前的患者。患者是在常规临床评估期间被识别出的。
干预： 从已进行的前庭测试、听力评估和影像学结果中收集数据。前庭功能通过冷热试验和视频头脉冲试验进行评估。病历数据通过医学访谈获得的最新信息加以补充。
主要结局指标： cCMV感染伴复发性或新发前庭功能障碍，以及单耳或双耳感音神经性听力损失。
结果： 12例年龄15至41岁、确诊cCMV感染的患者符合纳入标准。6例患者在10至12岁之间出现梅尼埃症状，4例在16至23岁之间出现，2例自儿童期即有听力损失，从30岁起发展为梅尼埃病。
结论与意义： cCMV感染可能代表年轻个体中内淋巴积水和梅尼埃病的一个独特亚组。这些发现强调了在出现内淋巴积水症状的年轻患者中考虑进行cCMV检测的重要性。
英文摘要
IMPORTANCE: Congenital cytomegalovirus (cCMV) is the most common cause of prenatal infection and the leading infectious cause of sensorineural hearing loss in childhood. Novel data indicate vestibular impairment is common in children with cCMV infection. Associations between endolymphatic hydrops and cCMV infection in humans are under debate, research reports are still scarce.
OBJECTIVE: To highlight a potential subgroup of Meniere's disease in young individuals and to support previous findings of recurrent vestibular impairment in children with cCMV infection.
DESIGN: A retrospective descriptive study of a clinical case series.
SETTING: Skåne University Hospital, Karolinska University Hospital and Sahlgrenska University Hospital in Sweden.
PARTICIPANTS: Patients with confirmed cCMV infection who presented with symptoms of Meniere's disease with onset before the age of 25. Patients were identified during routine clinical evaluations.
INTERVENTION: Data were collected from performed vestibular testing, hearing evaluations and imaging results. Vestibular function was assessed with caloric testing and the video head impulse test. Data from medical records were supplemented with updated information obtained from medical interviews.
MAIN OUTCOME MEASURES: cCMV infection with recurrent or newly developed vestibular impairment and sensorineural hearing loss in one or both ears.
RESULTS: Twelve patients aged 15 to 41 years, with confirmed cCMV infection met the inclusion criteria. Six patients experienced the onset of Meniere's symptoms between 10 and 12 years of age, 4 patients between 16 and 23 years old, and 2 with hearing loss since childhood, developed Meniere's disease from 30 years of age.
CONCLUSION AND RELEVANCE: cCMV infection may represent a distinct subgroup of endolymphatic hydrops and Meniere's disease in young individuals. These findings highlight the importance of considering cCMV testing in young patients presenting with symptoms of endolymphatic hydrops.