Article record

慢性鼻窦炎伴鼻息肉患者的疾病知识：一项多中心横断面研究

Patient knowledge in chronic rhinosinusitis with nasal polyps: a multicentre cross-sectional study.

临床研究鼻科IF 2.3Q1

文献信息

PMID	42806131
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Alvaro Sánchez Barrueco 查看其他 31 位作者 José Miguel Villacampa Aubá；Jesús Gimeno-Hernández；Daniel Finol Toro；Teresa Suárez Pérez；Katherine Yuen-Ato；Gema Gundín Rivas；Ithzel María Villarreal；Ainhoa García-Lliberós；Bárbara Serrano Calleja；Sara Zaldivar Saiz-Maza；Francisco J Rodríguez Domínguez；Alfonso Santamaría-Gadea；Henar González Rodríguez；Tomàs Pérez-Carbonell；Virginia Vasallo García；Miguel Mayo-Yáñez；Lina Rosique López；María Casasayas-Plass；Coloma Grau-van Laak；Daniela Cristina Páez Mantilla；Elisheba Haro Hernández；Blanca Mateos-Serrano；María Sandra Domínguez Sosa；María Soledad Cabrera Ramírez；Miriam Del Carmen Marrero Ramos；Natasha Pérez Marrero；Ignacio Clemente Agodino；Antonio de Oña Navarrete；María Casanova Ramón；Daniel Poletti Serafini；Christian Calvo-Henríquez
作者单位	Facultad de Ciencias Biomédicas y de la Salud, Universidad Alfonso X el Sabio (UAX), Avenida de la Universidad 1, Villanueva de la Cañada, Madrid, 28691, España. 查看其他 33 条单位信息 Rhinology and Anterior Skull Base Department, Service of Otolaryngology, Hospital Universitario General de Villalba, Collado Villalba, Spain.；Rhinology and Anterior Skull Base Department, Service of Otolaryngology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain.；Rhinology and Anterior Skull Base Department, Service of Otolaryngology, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain. jmvillacampa@fjd.es.；Medicine Faculty, Universidad Autónoma de Madrid (UAM), Madrid, Spain. jmvillacampa@fjd.es.；ENT and Cervicofacial Surgery Department, Hospital Universitario Fundación Jiménez Díaz, Av. de los Reyes Católicos, 2, Madrid, 28040, Spain. jmvillacampa@fjd.es.；Otolaryngology Head & Neck Surgery Department, Hospital Clínico San Carlos, Madrid, Spain.；Otolaryngology Head & Neck Surgery Department, Hospital Universitario Torrecárdenas, Almería, Spain.；Otolaryngology Head & Neck Surgery Department, Complejo Hospitalario Universitario de A Coruña (CHUAC), A Coruña, Spain.；Otolaryngology Head & Neck Surgery Department, Hospital Universitario Joan XXIII de Tarragona, Tarragona, Spain.；Otolaryngology Head & Neck Surgery Department, Hospital Universitario Infanta Cristina, Madrid, Spain.；Rhinology Unit, Otolaryngology Head & Neck Surgery Department, Fuenlabrada University Hospital, Nuestra Sra. del Rosario University Hospital, Madrid, Spain.；Otolaryngology and Head and Neck Surgery Department, Rhinology and Skull Base Section, Valencia University General Hospital, Valencia, Spain.；ENT and Head and Neck Surgery Department, Hospital Universitario de Toledo, Toledo, Spain.；Rhinology and Anterior Skull Base Department, Service of Otolaryngology, Hospital Universitario Infanta Elena, Valdemoro, Spain.；Rhinology, Service of Otolaryngology, Hospital Universitario Santa Lucía de Cartagena, Cartagena, Spain.；Medicine Faculty, Universidad Católica de Murcia (UCAM), Murcia, Spain.；Otolaryngology Department, Rhinology and Anterior Skull Base Unit, Hospital Universitario Ramón y Cajal, Madrid, Spain.；Otorhinolaryngology Research Group, Institute of Biomedical Research of A Coruña, (INIBIC), A Coruña, Spain.；Hospital Clínico Universitario de Valencia, Universidad de Valencia, Valencia, Spain.；Otorhinolaryngology - Head and Neck Surgery Department, Hospital San Rafael (HSR) de A Coruña, A Coruña, 15006, Spain.；Hospital Morales Meseguer, Murcia, Spain.；Otorhinolaryngology Department, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain.；Otolaryngology Head & Neck Surgery Department, Hospital Universitario La Paz, Madrid, Spain.；Otolaryngology Head & Neck Surgery Department, Hospital Universitario de Gran Canaria, Doctor Negrín, Las Palmas de Gran Canaria, Spain.；Otolaryngology Head & Neck Surgery Department, Hospital Universitario de San Roque, Las Palmas de Gran Canaria, Spain.；Otolaryngology Head & Neck Surgery Department, Hospital Universitario Príncipe de Asturias, Madrid, Spain.；Otolaryngology Head & Neck Surgery Department, Hospital Germans Trias i Pujol, Barcelona, Spain.；Otolaryngology Head & Neck Surgery Department, Vithas Virgen del Mar, Almería, Spain.；Rhinology and Anterior Skull Base Department, Service of Otolaryngology, Hospital General Universitario Gregorio Marañón, Madrid, Spain.；Rhinology Section, Hospital Universitario Nuestra Señora del Rosario, Madrid, Spain.；Medicine Faculty, San Pablo - CEU de Madrid, Madrid, Spain.；Rhinology Study Group of the Young-Otolaryngologists of the International Federations of Oto-Rhino-Laryngological Societies (YO-IFOS), Paris, France.；Service of Otolaryngology, Hospital Complex of Santiago de Compostela, Santiago de Compostela, Spain.
期刊	European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
SCI 分区	Q1
IF	2.3
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

目的： 描述慢性鼻窦炎伴鼻息肉（CRSwNP）患者的疾病相关知识特征，并识别在临床相关领域中与较高评分相关的因素。
方法： 在这项多中心横断面研究中，确诊为CRSwNP的成人在常规门诊诊疗期间完成了14个条目的SKQ-Pol和SNOT-22。连续百分比评分是主要校正结局。探索性分析评估了条目表现、信度、内部结构以及基于假设的构念关系。多变量模型包含医院随机截距；50%、60%和70%阈值仅在敏感性分析中检验。
结果： 在来自23家医院的791名参与者中，中位评分为35.7%（IQR 21.4-50.0）；12.0%的评分至少为60%。内部一致性为中等（KR-20 = 0.670；95% CI 0.63-0.70），内部结构分析不支持简单的单维度量表或可靠的子量表。在主要校正模型中，生物制剂治疗（+8.02个百分点，95% CI 5.03-11.01）、大学教育（+8.27，4.88-11.65）、研究生教育（+8.02，3.70-12.34）、更长的病程（+0.36/年，0.20-0.53）以及既往内镜鼻窦手术（+1.94/次手术，0.72-3.16）与较高评分相关。男性（-3.67，-6.12至-1.22）和年龄较大（-0.22/年，-0.32至-0.12）与较低评分相关。敏感性分析在方向上一致。
结论： 在所评估的CRSwNP领域中，知识总体较低。所识别的内容缺口及相关患者特征可能为针对性教育策略的前瞻性制定和评估提供信息。

英文摘要

PURPOSE: To characterize disease-related knowledge in chronic rhinosinusitis with nasal polyps (CRSwNP) and identify factors associated with higher scores across clinically relevant domains.
METHODS: In this multicentre cross-sectional study, adults with confirmed CRSwNP completed the 14-item SKQ-Pol and SNOT-22 during routine outpatient care. The continuous percentage score was the primary adjusted outcome. Exploratory analyses assessed item performance, reliability, internal structure, and hypothesis-based construct relationships. Multivariable models included a hospital random intercept; 50%, 60%, and 70% thresholds were examined only in sensitivity analyses.
RESULTS: Among 791 participants from 23 hospitals, the median score was 35.7% (IQR 21.4-50.0); 12.0% scored at least 60%. Internal consistency was moderate (KR-20 = 0.670; 95% CI 0.63-0.70), and internal-structure analyses did not support a simple unidimensional scale or reliable subscales. In the primary adjusted model, biologic treatment (+ 8.02% points, 95% CI 5.03-11.01), university education (+ 8.27, 4.88-11.65), postgraduate education (+ 8.02, 3.70-12.34), longer disease duration (+ 0.36 per year, 0.20-0.53), and previous endoscopic sinus surgery (+ 1.94 per procedure, 0.72-3.16) were associated with higher scores. Male sex (- 3.67, - 6.12 to - 1.22) and older age (- 0.22 per year, - 0.32 to - 0.12) were associated with lower scores. Sensitivity analyses were directionally consistent.
CONCLUSION: Knowledge across the assessed CRSwNP domains was generally low. The identified content gaps and associated patient profiles may inform the prospective development and evaluation of targeted educational strategies.