Article record

马提尼克岛以非裔加勒比裔为主的肥胖低通气综合征患者的死亡率及与死亡相关的危险因素

Mortality and risk factors associated with death in patients with obesity hypoventilation syndrome and of predominantly Afro-Caribbean origin in Martinique.

临床研究鼻科IF 3.8Q2

文献信息

PMID	42805766
原文	在 PubMed 查看原文 ↗
发表日期	2026
作者	Moustapha Agossou 查看其他 14 位作者 Astrid Monfort-Brafine；Cédric Fagour；Berenice Awanou；Salvatore Metanmo；Marie-Elodie Jean-Charles-Catan；Océane L'heveder；Jocelyn Inamo；Marion Duféal；Mathilde Provost；Nelly Ahouansou；Mathilde Andreu；Jean-Michel Arnal；Chantal Raherison-Semjen；Moustapha Dramé
作者单位	EpiCLIV unit, University Hospital of Martinique, Fort-de-France, Martinique, France moustapha.agossou@chu-martinique.fr. 查看其他 7 条单位信息 Department of Respiratory Medicine, University Hospital of Martinique, Fort-de-France, France.；Department of Cardiology, University Hospital of Martinique, Fort-de-France, France.；Department of Endocrinology and Diabetology, University Hospital of Martinique, Fort-de-France, France.；Department of Clinical Research and Innovation, University Hospital of Martinique, Fort-de-France, Martinique, France.；Service de réanimation polyvalente Unité de ventilation à domicile, Hopital Sainte Musse, Toulon, France.；Department of Respiratory Medicine, University Hospital of Guadeloupe, Pointe-A-Pitre, France.；EpiCLIV unit, University Hospital of Martinique, Fort-de-France, Martinique, France.
期刊	BMJ open respiratory research
SCI 分区	Q2
IF	3.8
研究类型	临床研究 · 临床
所属专科	鼻科

中文摘要

背景： 肥胖低通气综合征（OHS）是肥胖的一种呼吸系统并发症。OHS的死亡率不可忽视。OHS相关死亡的危险因素尚未明确，且文献中报道不一。本研究旨在评估马提尼克岛OHS患者的死亡率，并确定死亡的危险因素。
方法： 我们开展了一项单中心观察性研究，时间范围为2019年1月1日至2024年12月31日，纳入OHS患者。
结果： 在纳入的167例患者中，截至2024年12月31日，44例（26.4%）死亡。5年死亡率为12.6%。在多变量Cox回归中，死亡的独立预测因素包括：在急性呼吸衰竭期间诊断OHS（HR 6.60，95% CI 1.50至29.10）、随访不规律（HR 5，95% CI 1.82至14.29）、左心疾病（HR 3.63，95% CI 1.51至8.70）、较低的血细胞比容（每增加一个百分点HR 1.12，95% CI 1.03至1.22）以及诊断时年龄较大（每增加一岁HR 1.04，95% CI 1.01至1.08）。
结论： 马提尼克岛OHS患者的死亡率仍然很高。改善早期诊断、心血管风险管理及长期随访的策略对于改善这一高危人群的结局至关重要。

英文摘要

BACKGROUND: Obesity hypoventilation syndrome (OHS) is a respiratory complication of obesity. Mortality from OHS is non-negligible. Risk factors for OHS-related mortality are not well established and vary in the literature. This study aimed to assess mortality from OHS in patients in Martinique and to identify risk factors for death.
METHODS: We performed a single-centre, observational study from 1 January 2019 to 31 December 2024, including patients with OHS.
RESULTS: Among 167 included patients, 44 (26.4%) died as of 31 December 2024. 5-year mortality was 12.6%.In multivariable Cox regression, independent predictors of mortality were: OHS diagnosed during acute respiratory failure (HR 6.60, 95% CI 1.50 to 29.10), irregular follow-up (HR 5, 95% CI 1.82 to 14.29), left heart disease (HR 3.63, 95% CI 1.51 to 8.70), lower haematocrit (HR 1.12 per percentage point, 95% CI 1.03 to 1.22) and older age at diagnosis (HR 1.04 per year, 95% CI 1.01 to 1.08).
CONCLUSION: Mortality among patients with OHS in Martinique remains high. Strategies to improve early diagnosis, cardiovascular risk management and long-term follow-up are essential to improving outcomes in this high-risk population.