阻塞性睡眠呼吸暂停与可替宁之间的关联：基于2015-2020年NHANES的横断面研究
Associations Between Obstructive Sleep Apnea and Cotinine: A Cross-Sectional Study Based on 2015-2020 NHANES.
文献信息
| PMID | 42801662 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Qian Xue |
| 作者单位 | Department of Hepatobiliary Surgery, The People's Hospital of Leshan, Leshan, Sichuan, China. |
| 期刊 | Behavioral sleep medicine |
| SCI 分区 | Q3 |
| IF | 3.3 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
目的： 利用具有全国代表性的数据，探讨烟草暴露生物标志物（血清/尿液可替宁）与问卷定义的阻塞性睡眠呼吸暂停（OSA）之间的关联。
背景： 烟草暴露可能通过气道炎症和氧化应激与更高的OSA风险相关，但将尼古丁代谢物可替宁与OSA联系起来的人群水平证据仍然有限。
方法： 我们使用美国国家健康与营养调查（NHANES）睡眠问卷来识别患有OSA的参与者。根据血清可替宁水平，参与者被分为四组——非吸烟者、二手烟（SHS）暴露者、吸烟者和重度吸烟者。采用多变量logistic回归、亚组分析和敏感性分析来检验可替宁水平与问卷定义的OSA之间的关联。
结果： 我们分析了2015年至2020年3月收集的NHANES数据。在11,039名参与者中，1,700名（15.4%）被识别为患有OSA。Logistic回归显示，血清可替宁水平与OSA之间存在显著正相关（OR：1.04，95% CI：1.02-1.05，p < .001）。与非吸烟者相比，暴露于二手烟、吸烟者和重度吸烟者发生问卷定义OSA的比值分别高出1.28倍、1.37倍和1.53倍。尿液可替宁水平也与OSA显著相关（OR：1.04，95% CI：1.01-1.08，p = .02）。
结论： 主动吸烟和二手烟暴露均与问卷定义的OSA更高比值呈正相关。
英文摘要
OBJECTIVE: To investigate the associations between tobacco exposure biomarkers (serum/urinary cotinine) and questionnaire-defined obstructive sleep apnea (OSA) using nationally representative data.
BACKGROUND: Tobacco exposure may be associated with higher odds of OSA through airway inflammation and oxidative stress, but population-level evidence linking cotinine, a nicotine metabolite, to OSA remains limited.
METHODS: We used the National Health and Nutrition Examination Survey (NHANES) Sleep Questionnaire to identify participants with OSA.Participants were classified into four groups-nonsmokers, secondhand smoke (SHS) exposed, smokers, and heavy smokers - based on serum cotinine levels. Multivariable logistic regression, subgroup analyses, and sensitivity analyses were conducted to examine associations between cotinine levels and questionnaire-defined OSA.
RESULTS: We analyzed NHANES data collected from 2015 to March 2020. Among 11,039 participants, 1,700 (15.4%) were identified with OSA. Logistic regression showed a significant positive association between serum cotinine levels and OSA (OR: 1.04, 95% CI: 1.02-1.05, p < .001). Compared with nonsmokers, participants exposed to SHS, smokers, and heavy smokers had 1.28-, 1.37-, and 1.53-fold higher odds of questionnaire-defined OSA, respectively. Urinary cotinine levels were also significantly linked to OSA (OR: 1.04, 95% CI: 1.01-1.08, p = .02).
CONCLUSIONS: Both active smoking and SHS exposure are positively associated with higher odds of questionnaire-defined OSA.