主观短睡眠成人的睡眠呼吸障碍、睡眠时长与24小时动态血压
Sleep-disordered breathing, sleep duration, and 24-hour ambulatory blood pressure in subjective short-sleeping adults.
文献信息
| PMID | 42800139 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Kendal Chatard |
| 作者单位 | Department of Family and Preventive Medicine, Division of Public Health, University of Utah, United States of America. Electronic address: kendal.chatard@hsc.utah.edu. |
| 期刊 | Sleep medicine |
| SCI 分区 | Q1 |
| IF | 4.5 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
目的：
阻塞性睡眠呼吸暂停（OSA）和短睡眠时长各自均会增加高血压风险，但二者对24小时血压模式的联合影响仍鲜有描述。本研究评估了睡眠呼吸暂停严重程度（呼吸暂停低通气指数，AHI）、客观睡眠时长与动态血压（ABP）之间的关联。
方法：
本横断面二次分析使用了行为睡眠延长试验的数据，该试验纳入自我报告睡眠时长<7小时且诊室血压升高的成人。腕式活动记录仪测量客观睡眠时长，单夜家庭睡眠呼吸暂停检测评估OSA严重程度，参与者完成24小时ABP监测。采用线性回归评估AHI与平均收缩压/舒张压（DBP）之间的关联；采用logistic模型检验AHI与收缩压/舒张压非杓型的关联。
结果：
在195名数据有效的参与者中，AHI每升高10次/小时，在未调整模型（0.96 mmHg [95% CI 0.20, 1.71]；p = 0.013）和调整模型（0.92 mmHg [95% CI 0.10, 1.73]；p = 0.027）中均与更高的平均DBP相关。对于收缩压非杓型，未调整模型显示AHI越高，比值比越高（AHI每升高10次/小时的OR为1.34；95% CI 1.00至1.82；p = 0.049）。在调整年龄、性别、种族和BMI后，估计值方向相似，但未达到统计学显著性（OR 1.35；95% CI 0.97至1.97；p = 0.090）。AHI×睡眠时长对收缩压非杓型的交互作用p = 0.045。
结论：
在诊室血压升高且睡眠时长较短的成人中，OSA严重程度越高预示平均DBP越高。
英文摘要
OBJECTIVES: Obstructive sleep apnea (OSA) and short sleep duration each contribute to hypertension risk, yet their combined influence on 24-h blood pressure patterns remains poorly characterized. This study evaluated associations between sleep apnea severity (apnea-hypopnea index, AHI), objective sleep duration, and ambulatory blood pressure (ABP).
METHODS: This cross-sectional secondary analysis used data from a behavioral sleep extension trial which included adults with self-reported sleep duration <7 h and elevated in-office blood pressure. Wrist-worn actigraphy measured objective sleep duration, a single-night home sleep apnea test assessed OSA severity, and participants completed 24-h ABP monitoring. Linear regression evaluated associations between AHI and mean systolic/diastolic blood pressure (DBP); logistic models examined AHI associations with systolic/diastolic non-dipping.
RESULTS: Of 195 participants with valid data, each 10-event/hour higher AHI was associated with higher mean DBP in both the unadjusted model (0.96 mmHg [95% CI 0.20, 1.71]; p = 0.013) and the adjusted model (0.92 mmHg [95% CI 0.10, 1.73]; p = 0.027). For systolic non-dipping, the unadjusted model showed higher odds with higher AHI (OR per 10-event/hour higher AHI 1.34; 95% CI 1.00 to 1.82; p = 0.049). After adjustment for age, sex, race, and BMI, the estimate was similar in direction but did not meet statistical significance (OR 1.35; 95% CI 0.97 to 1.97; p = 0.090). The AHI × sleep duration interaction for systolic non-dipping had p = 0.045.
CONCLUSIONS: Among adults with elevated in-office blood pressure and short sleep duration, greater OSA severity predicted higher mean DBP.