食物过敏与显著更高的特应性共病负担及增加的医疗服务使用相关。
Food Allergies Are Associated With a Substantially Higher Burden of Atopic Comorbidities and Increased Healthcare Use.
文献信息
| PMID | 42799315 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Anna Berezin Shoham |
| 作者单位 | Medical Division, Maccabi Healthcare Services, Tel Aviv, Israel. |
| 期刊 | Acta paediatrica (Oslo, Norway : 1992) |
| SCI 分区 | Q2 |
| IF | 2.4 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 鼻科 |
中文摘要
目的： 我们评估了食物过敏儿童中特应性共病的患病率及医疗服务使用情况。
方法： 这项回顾性匹配队列研究使用了一家大型健康维护组织的数据，该组织承保并提供全民医疗服务。2001年至2019年间诊断为食物过敏的0-18岁儿童按1:1与非过敏对照匹配。比较了人口统计学、共病率和医疗服务使用数据。计算了调整比值比（aOR）和置信区间（CI）。
结果： 我们识别了20,418名食物过敏儿童，并将其与20,418名对照匹配。病例组的过敏性共病率显著更高，包括过敏性鼻炎（aOR 2.09，95% CI 1.95-2.25）、特应性皮炎（aOR 2.04，95% CI 1.94-2.14）和嗜酸性食管炎（aOR 15.4，95% CI 6.04-39.55；104例 vs. 5例事件）。大多数处方率显著升高，尤其是水解配方奶粉（aOR 12.32，95% CI 10.83-14.0）。专科会诊更频繁，增幅最大的是胃肠病学（aOR 2.23，95% CI 2.09-2.37）和肺病学（aOR 2.03，95% CI 1.90-2.17）。一般医疗服务使用更高，包括急诊科就诊和住院。
结论： 在这个大型全国队列中，儿童食物过敏与显著更高的特应性共病负担及增加的医疗服务使用相关。
英文摘要
AIM: We assessed the prevalence of atopic comorbidities and healthcare service use among children with food allergies.
METHODS: This retrospective matched cohort study used data from a large health maintenance organisation, which insures and provides universal healthcare services. Children aged 0-18 years who were diagnosed with food allergies from 2001 to 2019 were matched 1:1 with non-allergic controls. Data on demographics, rate of comorbidities, and healthcare use were compared. Adjusted odds ratios (aOR) and confidence intervals (CI) were calculated.
RESULTS: We identified 20 418 children with food allergies and matched them to 20 418 controls. Cases had significantly higher rates of allergic comorbidities, including allergic rhinitis (aOR 2.09, 95% CI 1.95-2.25), atopic dermatitis (aOR 2.04, 95% CI 1.94-2.14), and eosinophilic esophagitis (aOR 15.4, 95% CI 6.04-39.55; 104 vs. 5 events). Most prescription rates were markedly elevated, particularly for hydrolysed formulas (aOR 12.32, 95% CI 10.83-14.0). Specialist consultations were more frequent, with the greatest increases in gastroenterology (aOR 2.23, 95% CI 2.09-2.37) and pulmonology (aOR 2.03, 95% CI 1.90-2.17). General healthcare use was higher, including emergency department visits and hospitalisations.
CONCLUSION: Paediatric food allergies were associated with a substantially higher burden of atopic comorbidities and increased healthcare use in this large national cohort.