ln(FPG/HDL-C) × BMI 与自报阻塞性睡眠呼吸暂停之间的关联：一项使用 NHANES 数据的横断面研究。

文献信息

中文摘要

背景： 阻塞性睡眠呼吸暂停（OSA）与空腹血糖、高密度脂蛋白胆固醇和体重指数有关。然而，OSA 与 ln[(空腹血糖)/(高密度脂蛋白胆固醇)] × 体重指数（FHB）指数：计算为 ln(FPG/HDL-C) × BMI：之间的关联尚未在美国成年人中得到广泛研究。本研究旨在探讨 FHB 指数是否与美国成年人自报 OSA 症状的风险相关。方法：分析利用了 2005 至 2008 年和 2015 至 2018 年调查周期收集的全国健康与营养调查数据集。应用加权多变量回归和曲线拟合来探索 FHB 指数与 OSA 的相关性，同时进行亚组和敏感性分析以评估这种关系的一致性。结果：在 7414 名研究对象中，3694 人报告了 OSA 症状。曲线拟合显示 FHB 指数与 OSA 风险呈非线性正相关（非线性 P < .001），确定的阈值为 25.84。低于该值时，FHB 指数每增加 1 个单位与 OSA 风险增加 5.2% 相关（比值比 [OR] = 1.052；95% 置信区间 [CI]：1.009-1.096）。高于该值时，每增加 1 个单位与增加 2.6% 相关（OR = 1.026；95% CI：1.022-1.031）。当 FHB 指数作为分类变量分析时，FHB 指数第三分位数的个体患 OSA 的几率比第一分位数的个体高 211.9%（OR = 3.119；95% CI：2.675-3.635）。亚组和敏感性分析证实了这种关联的稳健性。结论：这项横断面研究揭示了美国成年人中 FHB 指数与自报 OSA 之间的非线性正相关关系。FHB 指数可能作为一种新颖且方便的候选标志物，用于识别 OSA 高风险个体，值得进一步研究。然而，在考虑临床应用之前，这些发现需要通过纵向研究进行验证。

英文摘要

Obstructive sleep apnea (OSA) is linked to fasting plasma glucose, high-density lipoprotein cholesterol, and body mass index. However, the association between OSA and the ln[(fasting plasma glucose)/(high-density lipoprotein cholesterol)] × body mass index (FHB) index: calculated as ln(FPG/HDL-C) × BMI: has not been extensively investigated in US adults. This research aims to investigate whether the FHB index is associated with the risk of self-reported OSA symptoms among US adults. The analysis utilized National Health and Nutrition Examination Survey datasets collected during the 2005 to 2008 and 2015 to 2018 survey cycles. Weighted multivariable regression and curve fitting were applied to explore the FHB index-OSA correlation, while subgroup and sensitivity analyses were conducted to evaluate the consistency of this relationship. Among 7414 study subjects, 3694 reported symptoms of OSA. Curve fitting showed a nonlinear positive relationship of the FHB index for OSA risk (P for nonlinearity <.001), with an identified threshold of 25.84. Below this value, each 1-unit increase in the FHB index was linked to a 5.2% increase in OSA risk (odds ratio [OR] = 1.052; 95% confidence interval [CI]: 1.009-1.096). Above this value, each 1-unit increase was linked to a 2.6% increase (OR = 1.026; 95% CI: 1.022-1.031). When the FHB index was analyzed as a categorical variable, individuals in the third tertile of the FHB index had odds of OSA that were 211.9% higher than those in the first tertile (OR = 3.119; 95% CI: 2.675-3.635). Subgroup and sensitivity analyses confirmed the robustness of this association. This cross-sectional study revealed a nonlinear positive relationship between the FHB index and self-reported OSA among US adults. The FHB index may serve as a novel and convenient candidate marker for identifying individuals at high-risk of OSA, meriting further investigation. However, before considering clinical application, these findings require validation through longitudinal studies.