基于16年全国性纵向数据的慢性肾脏病与新发梅尼埃病之间的关联
Association Between Chronic Kidney Disease and Incident Ménière's Disease Using 16 Years of Nationwide Longitudinal Data.
文献信息
| PMID | 42796100 |
|---|---|
| 原文 | 在 PubMed 查看原文 ↗ |
| 发表日期 | 2026 |
| 作者 | Eun Soo Kim |
| 作者单位 | Department of Radiology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Republic of Korea. |
| 期刊 | Journal of clinical medicine |
| SCI 分区 | Q1 |
| IF | 3.5 |
| 研究类型 | 临床研究 · 临床 |
| 所属专科 | 耳科 |
中文摘要
背景： 尽管慢性肾脏病（CKD）已与多种形式的听觉和前庭功能障碍相关，但其与梅尼埃病（MD）的关系在人群水平上尚未得到充分确立。我们在一个大型全国性队列中研究了CKD是否与随后发生MD相关。方法：数据来自韩国国民健康保险服务-健康筛查队列，时间为2002-2019年。分析纳入15,943名CKD参与者和63,772名对照参与者，按年龄、性别、家庭收入和居住地区以1:4比例匹配。此外应用倾向评分重叠加权以平衡测得的基线特征。使用Cox比例风险模型估计新发MD的风险比（HR）和95%置信区间（CI）。结果：在CKD组67,471人年和对照组330,701人年的随访期间，分别有173名和903名参与者发生MD。粗HR为0.92（95% CI，0.79-1.09；p = 0.346），重叠加权点估计为0.95（95% CI，0.84-1.07；p = 0.414）。结论：可用的点估计并未表明CKD参与者中新发MD的风险更高，但应谨慎解释这些发现，因为无法评估加权方差估计，且死亡未作为竞争事件建模。有必要开展保留前瞻性个体水平数据和竞争风险分析的进一步研究。
英文摘要
Background: Although chronic kidney disease (CKD) has been associated with several forms of auditory and vestibular impairment, its relationship with Ménière's disease (MD) has not been well established at the population level. We investigated whether CKD is associated with subsequent development of MD in a large national cohort. Methods: Data were obtained from the Korean National Health Insurance Service-Health Screening Cohort for 2002-2019. The analysis included 15,943 participants with CKD and 63,772 comparison participants matched at a 1:4 ratio according to age, sex, household income, and region of residence. Propensity-score overlap weighting was additionally applied to balance measured baseline characteristics. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incident MD. Results: During 67,471 person-years of follow-up in the CKD group and 330,701 person-years in the comparison group, 173 and 903 participants, respectively, developed MD. The crude HR was 0.92 (95% CI, 0.79-1.09; p = 0.346), and the overlap-weighted point estimate was 0.95 (95% CI, 0.84-1.07; p = 0.414). Conclusions: The available point estimates did not indicate a higher hazard of incident MD among participants with CKD, but the findings should be interpreted cautiously because weighted variance estimation could not be evaluated and death was not modeled as a competing event. Further studies with prospectively retained individual-level data and competing-risk analyses are warranted.