磁共振成像造影剂钆特酸具有耳毒性吗？

文献信息

中文摘要

目的： 对比增强磁共振成像（MRI）可在有症状和无症状耳中显示内淋巴积水。积水的影像学可视化对梅尼埃病的诊断很重要；然而，鼓室内注射钆特酸的耳毒性仍不清楚。本研究旨在通过听性脑干反应（ABR）测试和组织病理学方法，探讨不同剂量鼓室内注射钆特酸的耳毒性。
方法： 将40只健康雄性Wistar Albino大鼠随机分为四组。使用ABR测试在10、16和24 kHz检查不同稀释度的钆特酸对内耳的影响。将基线测量值与注射后第1天和第14天的测量值进行比较。完成最终测量后，处死大鼠，取样在光镜下进行组织病理学检查。
结果： 在大鼠鼓室内注射钆特酸后，基于ABR测试和组织病理学检查在第1天和第14天评估耳毒性。ABR测量表明，纯钆特酸导致10、16和24 kHz的听力阈值显著下降。相比之下，稀释制剂的阈值偏移不显著。组织病理学检查未显示显著差异。
结论： 根据ABR测试，在鼓室内注射未稀释的钆特酸后第14天检测到耳毒性。将钆特酸与生理盐水按1:16比例稀释似乎是最安全的剂量。本文的证据等级为5。本文是一项实验动物和实验室研究。

英文摘要

OBJECTIVE: Contrast Magnetic Resonance Imaging (MRI) reveals endolymphatic hydrops in both symptomatic and asymptomatic ears. Radiological visualization of hydrops is important in the diagnosis of Meniere's disease; however, the ototoxicity of intratympanically administered gadoteric acid remains unknown. To investigate the ototoxicity of the intratympanic administration of gadoteric acid at different doses using an Auditory Brainstem Response (ABR) test and histopathological methods.
METHODS: Forty healthy male Wistar Albino rats were randomly divided into four groups. The effect of different dilutions of gadoteric acid on the inner ear was examined using the ABR test at 10, 16, and 24 kHz. Basal measurements were compared with those at 1 and 14 days after injection. After completing the final measurements, the rats were sacrificed, and samples were taken for histopathological examination under light microscopy.
RESULTS: Following the intratympanic administration of gadoteric acid in rats, the ototoxicity was evaluated on days-1 and -14 based on ABR testing and histopathological examination. The ABR measurements demonstrated that pure gadoteric acid caused a significant decrease in the hearing threshold at 10, 16, and 24 kHz. By contrast, threshold shifts were not significant with diluted preparations. Histopathological examination revealed no significant differences.
CONCLUSION: Ototoxicity was detected on day-14 following the intratympanic administration of undiluted gadoteric acid, determined by ABR testing. The dilution of gadoteric acid with saline at a 1:16 ratio appeared to be the safest dose. The level of evidence of this article is 5. This article is an experimental animal and laboratory study.